EFFECTS OF VISUAL DEPRIVATION ON MORPHOLOGY AND PHYSIOLOGY OF CELLS IN CATS LATERAL GENICULATE BODY
EFFECTS OF VISUAL DEPRIVATION ON MORPHOLOGY AND PHYSIOLOGY OF CELLS IN CATS LATERAL GENICULATE BODY
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DOI：
10.1152/jn.1963.26.6.978
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发表时间：
1963-01-01
影响因子：
2.5
通讯作者：
HUBEL, DH
中科院分区：
文献类型：
--
作者：
WIESEL, TN;HUBEL, DH
通过单眼眼睑缝合或在角膜上放置半透明接触性遮挡物，使小猫失去光和形状。在出生后单眼眼睑缝合3个月的小猫中，大多数接受剥夺眼输入的外侧膝状体细胞具有正常的感受野；少数细胞的感受野中心异常大。观察到明显的组织学变化；接受剥夺眼输入的层中的细胞平均面积减少了多达40%；细胞核和核仁缩小。在视网膜、视神经、上丘或纹状皮质中未观察到变化。在单眼眼睑缝合3个月的成年猫中未观察到组织学变化。出生后或较短时间被剥夺的小猫表现出的变化不太严重。
Kittens were deprived of light and form by monocular lid suture or by placing a translucent contact occluder over the cornea. In kittens with one lid sutured from birth for 3 months most lateral geniculate cells with input from the deprived eye had normal receptive fields; a few had fields with abnormally large centres. Marked histological changes were seen; mean areas of cells in layers having input from the deprived eye were decreased by up to 40%; nuclei and nucleoli were shrunken. No changes were seen in retinas, optic nerves, superior colliculi or striate cortex. No histological changes were seen in an adult cat monocularly deprived by lid suture for 3 months. Kittens deprived subsequent to birth or for shorter periods showed less severe changes.