Probiotics in the treatment of chronic kidney disease: a systematic review
Probiotics in the treatment of chronic kidney disease: a systematic review
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DOI：
10.1590/2175-8239-jbn-3931
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发表时间：
2018-09-01
期刊：
影响因子：
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通讯作者：
Mendes, Roberta Hack
中科院分区：
文献类型：
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作者：
Fagundes, Raquel Aparecida Bandeira;Soder, Taís Fátima;Mendes, Roberta Hack
慢性肾脏病(CKD)是由肾功能进行性减退引起的综合征。本研究旨在系统探讨益生菌在慢性肾脏病治疗中的作用。检索数据库MEDLINE(PubMed)、SciELO、Cochrane和临床试验。两位独立的评价者选择了从中提取数据的研究。搜索包括2012-2016年间发表的描述随机临床试验的英语和葡萄牙语论文。82篇符合条件的文章中有8篇符合入选标准。样本量从18到101名慢性肾脏病患者。纳入研究的持续时间从4周到24周不等。大多数纳入的文章报道了对肾功能的积极影响和降低尿素、血尿素氮、氨、血浆对甲酚、对甲酚硫酸盐和吲哚硫酸盐的水平。
Chronic kidney disease (CKD) is a syndrome caused by the progressive reduction of renal function. This study aimed to systematically examine the effects of supplementation with probiotics in the treatment of CKD. Searches were carried out on databases MEDLINE (PubMed), SciELO, Cochrane, and Clinical Trials. Two independent reviewers selected the studies from which data was extracted. The search included papers written in English and Portuguese published in the 2012-2016 period describing randomized clinical trials. Eight of the 82 eligible articles met the inclusion criteria. Sample size ranged from 18 to 101 individuals with CKD. The duration of the included studies varied from four to 24 weeks. Most of the included articles reported positive effects in renal function and decreased levels of urea, blood urea nitrogen, ammonia, plasma p-cresol, p-cresyl sulfate, and indoxyl sulfate.