Fungus as the cause of chronic rhinosinusitis: the case remains unproven
Fungus as the cause of chronic rhinosinusitis: the case remains unproven
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DOI：
10.1097/moo.0b013e32831de91e
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发表时间：
2009-02-01
影响因子：
1.6
通讯作者：
Fokkens, Wytske J.
中科院分区：
文献类型：
--
作者：
Ebbens, Fenna A.;Georgalas, Christos;Fokkens, Wytske J.
综述目的回顾有关真菌在慢性鼻鼻窦炎（CRS）发病机制中的作用以及抗真菌药物治疗和抗真菌免疫治疗效果的文献。最近的发现本文回顾了最近研究真菌在CRS发病机制中的作用的文章。除了可能异常的先天性和适应性抗真菌免疫反应和真菌抗宿主作用，这一切都可以解释疾病的发展，抗真菌药物治疗和抗真菌免疫治疗的效果review.SummaryAlthough真菌可以检测到在鼻子和鼻旁窦的几乎所有患者的CRS和存在于几乎所有的健康对照，各种研究表明，可能存在真菌仅对易感个体的窦粘膜产生影响的机制。未来的研究将必须澄清真菌在CRS中的作用，哪些真菌生物体可能是致病的，以及对真菌的免疫反应的确切特征可能导致疾病的发展。目前，由于缺乏令人信服的免疫学数据和抗真菌药物治疗后CRS临床改善的证据，对抗真菌的病例仍未得到证实。
Purpose of reviewTo review the literature on the role of fungi in chronic rhinosinusitis (CRS) pathogenesis and the effect of antifungal drug therapy and antifungal immunotherapy.Recent findingsThis paper reviews the most recent articles investigating the role of fungi in CRS pathogenesis. In addition to possible aberrant innate and adaptive antifungal immune responses and fungus antihost effects, which all may explain disease development, the effect of antifungal drug therapy and antifungal immunotherapy is reviewed.SummaryAlthough fungi can be detected in the nose and paranasal sinuses of nearly all patients with CRS and are present in almost all healthy controls, various studies suggest that there may be mechanisms by which fungi exert an effect on sinus mucosa in susceptible individuals only. Future studies will have to clarify the role of fungi in CRS, which fungal organisms, if at all, may be pathogenic and what exactly characterizes the immunological response to fungi that potentially results in the development of disease. Presently, in the absence of convincing immunological data and evidence for clinical improvement of CRS upon therapy with antifungal agents, the case against the fungus remains unproven.