Frontiers in growth and remodeling.
Frontiers in growth and remodeling.
复制标题
DOI：
10.1016/j.mechrescom.2012.02.007
复制
发表时间：
2012-06-01
影响因子：
2.4
通讯作者：
Kuhl E
中科院分区：
文献类型：
--
作者：
Menzel A;Kuhl E
与普通的工程材料不同，生物可以自主地对环境变化做出反应。由于不断的微观结构周转和更新，活的结构可以在几个月、几周或几天内变得更强、更弱、更大或更小。硬组织可以通过增加它们的密度来适应，并变得强壮。软组织可以通过增加它们的体积来适应，并长得更大。三十多年来，力学学界为从力学角度理解生长和重塑现象作出了积极贡献。然而，到目前为止，该领域的所有科学家都平等地接受了对生长的单一、统一的描述。在这里，我们阐明了生物生长和重塑的连续统模型，并对历史发展和趋势进行了全面的概述。我们提供了当前研究亮点的最新回顾，并讨论了挑战和潜在的未来方向。以体积生长为例，我们说明了如何建立和利用生长理论来描述软生物的功能适应。我们预计这篇综述将成为生长和重塑方面的关键讨论和未来研究的起点，对生命科学和医学具有潜在的影响。
Unlike common engineering materials, living matter can autonomously respond to environmental changes. Living structures can grow stronger, weaker, larger, or smaller within months, weeks, or days as a result of a continuous microstructural turnover and renewal. Hard tissues can adapt by increasing their density and grow strong. Soft tissues can adapt by increasing their volume and grow large. For more than three decades, the mechanics community has actively contributed to understand the phenomena of growth and remodeling from a mechanistic point of view. However, to date, there is no single, unified characterization of growth, which is equally accepted by all scientists in the field. Here we shed light on the continuum modeling of growth and remodeling of living matter, and give a comprehensive overview of historical developments and trends. We provide a state-of-the-art review of current research highlights, and discuss challenges and potential future directions. Using the example of volumetric growth, we illustrate how we can establish and utilize growth theories to characterize the functional adaptation of soft living matter. We anticipate this review to be the starting point for critical discussions and future research in growth and remodeling, with a potential impact on life science and medicine.
登录
查看更多内容
影响因子：
2.4
作者：
Ciarletta, Pasquale;Ben Amar, Martine
通讯作者：
Ben Amar, Martine
影响因子：
2
作者：
Chen, YC;Hoger, A
通讯作者：
Hoger, A
DOI：
10.1016/s0045-7825(97)00158-8
发表时间：
1998-03-30
影响因子：
7.2
作者：
Betsch, P;Menzel, A;Stein, E
通讯作者：
Stein, E
影响因子：
2.2
作者：
Abilez, O;Benharash, P;Zarins, C
通讯作者：
Zarins, C
影响因子：
5.3
作者：
Ben Amar, M;Goriely, A
通讯作者：
Goriely, A