The Evolving Role of Radiation Therapy in the Treatment of Biliary Tract Cancer.
The Evolving Role of Radiation Therapy in the Treatment of Biliary Tract Cancer.
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DOI：
10.3389/fonc.2020.604387
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发表时间：
2020
影响因子：
4.7
通讯作者：
Brunner TB
中科院分区：
文献类型：
--
作者：
Gkika E;Hawkins MA;Grosu AL;Brunner TB
胆道癌(BTC)是一种由多种上皮性肿瘤组成的疾病，根据其解剖位置可分为肝内(ICCA)、肝门周围(PCCA)、远端(DCCA)胆管癌和胆囊癌(GBC)，具有不同的流行病学、生物学和预后。完全手术切除是可手术的BTC的支柱，因为它是唯一有可能治愈的治疗选择。然而，即使在根治性(R0)切除后，5年生存率在20%至40%之间，无病生存率(DFS)在1年后约为48%至65%，在未经辅助治疗的3年后约为23%至35%。辅助化疗的改进改善了DFS，但辅助放射治疗的作用尚不清楚。另一方面，超过50%的患者在确诊时存在无法切除的疾病，这将预后限制在几个月内而不进行治疗。在此，我们回顾了放射治疗在治疗和姑息治疗胆管细胞癌中的作用。
Biliary tract cancers (BTC) are a disease entity comprising diverse epithelial tumors, which are categorized according to their anatomical location as intrahepatic (iCCA), perihilar (pCCA), distal (dCCA) cholangiocarcinomas, and gallbladder carcinomas (GBC), with distinct epidemiology, biology, and prognosis. Complete surgical resection is the mainstay in operable BTC as it is the only potentially curative treatment option. Nevertheless, even after curative (R0) resection, the 5-year survival rate ranges between 20 and 40% and the disease free survival rates (DFS) is approximately 48–65% after one year and 23–35% after three years without adjuvant treatment. Improvements in adjuvant chemotherapy have improved the DFS, but the role of adjuvant radiotherapy is unclear. On the other hand, more than 50% of the patients present with unresectable disease at the time of diagnosis, which limits the prognosis to a few months without treatment. Herein, we review the role of radiotherapy in the treatment of cholangiocarcinoma in the curative and palliative setting.
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影响因子：
3.8
作者：
Bonet Beltran, Marta;Roth, Arnaud D.;Allal, Abdelkarim S.
通讯作者：
Allal, Abdelkarim S.
DOI：
10.1016/j.bpg.2016.08.003
发表时间：
2016-08-01
影响因子：
3.2
作者：
Brunner, Thomas B.;Seufferlein, Thomas
通讯作者：
Seufferlein, Thomas
影响因子：
6.2
作者：
Cao, Hop S. Tran;Zhang, Qianzi;Massarweh, Nader N.
通讯作者：
Massarweh, Nader N.
影响因子：
3.7
作者：
Choi, Sae-Byeol;Kim, Kyung-Sik;Chung, Jae-Bock
通讯作者：
Chung, Jae-Bock
DOI：
10.1186/1748-717x-7-67
发表时间：
2012-05-03
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Barney BM;Olivier KR;Miller RC;Haddock MG
通讯作者：
Haddock MG