Study of TLR3, TLR4, and TLR9 in prostate carcinomas and their association with biochemical recurrence
Study of TLR3, TLR4, and TLR9 in prostate carcinomas and their association with biochemical recurrence
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DOI：
10.1007/s00262-010-0931-0
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发表时间：
2011-02-01
影响因子：
5.8
通讯作者：
Vizoso, Francisco J.
中科院分区：
文献类型：
--
作者：
Gonzalez-Reyes, Salome;Fernandez, Jesus M.;Vizoso, Francisco J.
Toll样受体（TLR）由于其在肿瘤进展中的作用，在癌症研究中引起了极大的兴趣。通过激活几种生物因子的产生，TLR诱导I型干扰素和其他细胞因子，其驱动炎症反应并激活适应性免疫系统。为探讨TLR3、TLR4和TLR9在前列腺癌中的表达及其临床意义，检测了133例前列腺癌患者肿瘤组织中TLR3、TLR4和TLR9的表达水平。采用组织芯片免疫组化和真实的时间PCR方法分析肿瘤细胞TLRs的表达情况。复发癌的样品显示TLR3、TLR4和TLR9的mRNA水平显著增加。另外，TLR3或TLR9高表达的肿瘤与生化复发的可能性显著相关，TLR表达与前列腺癌复发相关，TLR受体在恶性肿瘤生物学中的作用值得研究。增强或阻断TLR的治疗策略可能是令人感兴趣的。
Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive an inflammatory response and activate the adaptive immune system. The aim of this study was to investigate the expression and clinical relevance of TLR3, 4, and 9 in prostate cancer.The expression levels of TLR3, TLR4, and TLR9 were analyzed on tumors from 133 patients with prostate cancer. The analyses were performed by immunohistochemistry on tissue arrays and real time-PCR.Cancerous cells showed high expression levels of TLRs compared with controls. Samples of carcinomas with recurrence exhibited a significant increase in the mRNA levels of TLR3, TLR4, and TLR9. In addition, the tumors that showed high TLR3 or TLR9 expression levels were significantly associated with higher probability of biochemical recurrence.TLR expression is associated with prostate cancer with recurrence and the role of TLR receptors in the biology of malignancy merits study. Therapeutic strategies to boost or block TLRs may be of interest.