Catch-up growth and catch-up fat in children born small for gestational age.
Catch-up growth and catch-up fat in children born small for gestational age.
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DOI：
10.3345/kjp.2016.59.1.1
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发表时间：
2016-01
影响因子：
--
通讯作者：
Suh BK
中科院分区：
文献类型：
--
作者：
Cho WK;Suh BK
小于胎龄儿（SGA）出生的婴儿在以后的生活中围产期发病率，持续性身材矮小和代谢改变的风险增加。最近的研究集中在出生体重（BW）和后来的身体组成之间的关联。一些报告表明，胎儿营养，反映了体重，可能有一个反向编程的影响腹部肥胖以后的生活。体重与成人腹部肥胖之间的这种负相关可能导致胰岛素抵抗。婴儿期体重快速增加的SGA儿童似乎与脂肪量增加有关，而不是与瘦体重有关。SGA出生后的早期追赶性生长，而不是SGA本身，被认为是晚年心血管疾病的危险因素。出生时患有SGA的儿童也有脂肪量积累的倾向，特别是腹内脂肪。目前尚不清楚这种倾向是由于低BW本身，出生后快速追赶生长，还是两者兼而有之。在这份报告中，我们回顾了已发表的文献中的中央脂肪积累和代谢的后果是SGA，以及目前流行的研究领域的SGA，包括生长方面。
Infants born small for gestational age (SGA) are at increased risk of perinatal morbidity, persistent short stature, and metabolic alterations in later life. Recent studies have focused on the association between birth weight (BW) and later body composition. Some reports suggest that fetal nutrition, as reflected by BW, may have an inverse programing effect on abdominal adiposity later in life. This inverse association between BW and abdominal adiposity in adults may contribute to insulin resistance. Rapid weight gain during infancy in SGA children seemed to be associated with increased fat mass rather than lean mass. Early catch-up growth after SGA birth rather than SGA itself has been noted as a cardiovascular risk factor in later life. Children who are born SGA also have a predisposition to accumulation of fat mass, particularly intra-abdominal fat. It is not yet clear whether this predisposition is due to low BW itself, rapid postnatal catch-up growth, or a combination of both. In this report, we review the published literature on central fat accumulation and metabolic consequences of being SGA, as well as the currently popular research area of SGA, including growth aspects.