Genetic variation, C-reactive protein levels, and incidence of diabetes
Genetic variation, C-reactive protein levels, and incidence of diabetes
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DOI：
10.2337/db06-0922
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发表时间：
2007-03-01
期刊：
影响因子：
7.7
通讯作者：
Witteman, Jacqueline C. M.
中科院分区：
文献类型：
--
作者：
Dehghan, Abbas;Kardys, Isabella;Witteman, Jacqueline C. M.
C-反应蛋白（CRP）已被证明与2型糖尿病有关，但CRP是否具有因果作用尚不清楚。我们在鹿特丹研究（一项基于人群的前瞻性队列研究）中检查了这种关联。研究基线血清CRP与随访期间发生的糖尿病之间的关系，并对BMI校正后的CRP与糖尿病之间的关系进行荟萃分析。此外，CRP单倍型与血清CRP和糖尿病的风险进行了评估。经年龄和性别校正的糖尿病风险比为1.41（95%CI 1.29-1.54），CRP的自然对数每增加1 SD，与第一四分位数相比，CRP的第二四分位数分别为1.88、2.16和2.83。风险评估减弱，但在对肥胖指数进行额外调整后仍具有统计学意义，这与荟萃分析的结果一致。与其他三种单倍型相比，最常见的遗传单倍型与显著较低的CRP水平相关。与最常见的单倍型相比，血清CRP水平最高的单倍型的糖尿病风险显著更高（OR 1.45，95%CI 1.08-1.96）。这些发现支持血清CRP促进糖尿病发展的假设。
C-reactive protein (CRP) has been shown to be associated with type 2 diabetes, but whether CRP has a causal role is not yet clear. We examined the association in the Rotterdam Study, a population-based prospective cohort study. The association of baseline serum CRP and incident diabetes during follow-up was investigated, and a meta-analysis was conducted on the BMI-adjusted relation of CRP and diabetes. Furthermore, the association of CRP haplotypes with serum CRP and risk of diabetes was assessed. The age- and sex-adjusted hazard ratio for diabetes was 1.41 (95% CI 1.29-1.54) per 1 SD increase in natural logarithm of CRP, and it was 1.88, 2.16, and 2.83 for the second, third, and fourth quartiles of CRP, respectively, compared with the first quartile. The risk estimates attenuated but remained statistically significant after additional adjustment for obesity indexes, which agreed with the results of the meta-analysis. The most common genetic haplotype was associated with a significantly lower CRP level compared with the three other haplotypes. The risk of diabetes was significantly higher in the haplotype with the highest serum CRP level compared with the most common haplotype (OR 1.45, 95% CI 1.08-1.96). These findings support the hypothesis that serum CRP enhances the development of diabetes.