Risk of developing cytomegalovirus retinitis in persons infected with the human immunodeficiency virus.
Risk of developing cytomegalovirus retinitis in persons infected with the human immunodeficiency virus.
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感染人类免疫缺陷病毒的人有患巨细胞病毒性视网膜炎的风险。
DOI：
10.1097/00006982-199313030-00016
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Robert L. Murphy
中科院分区：
文献类型：
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作者：
Peter Pertel;R. E. Hirschtick;John P. Phair;Joan S. Chmiel;Linda Poggensee;Robert L. Murphy
这项研究研究了出现巨细胞病毒（CMV）视网膜炎的风险，这是CD4+淋巴细胞耗竭的持续时间和程度的函数。对感染人类免疫缺陷病毒（HIV）感染的135人进行了回顾性分析。计算了27个月的研究期间患者患者的CMV视网膜炎患者百分比的估计值。 26例患者被诊断为患有CMV视网膜炎。在其中14例患者中，在诊断之前的3个月内进行了T细胞表型。这些患者的平均CD4+淋巴细胞计数为15.6细胞/mm3（范围为2-33/mm3）。在27个月时，患有基线CD4+淋巴细胞计数为0-50、51-100和101-250细胞/mm3的患者百分比分别为41.9％，26.3％和14.7％（对数秩检验，分别为14.7％） p = 0.003）。与101-250细胞/mm3的CD4+淋巴细胞计数相比，基线CD4+淋巴细胞计数为0-50细胞/mm3的基线CMV视网膜炎的优势比为0-50细胞/mm3（p = 0.002）。二十四名患者的CD4+淋巴细胞计数为<OR = 50个细胞/mm3，平均在诊断前13.1个月。 22例患者患有因视网膜炎发作前平均18.0个月诊断出的可诊断出的免疫缺陷综合征（AIDS）。当CD4+淋巴细胞计数为<OR = 50细胞/mm3时，CMV视网膜炎最有可能在AIDS患者中发育。
This study examines the risk of developing cytomegalovirus (CMV) retinitis as a function of the duration and degree of CD4+ lymphocyte depletion. A retrospective analysis of 135 persons infected with the human immunodeficiency virus (HIV) was performed. Kaplan-Meier estimates for the percentage of patients developing CMV retinitis during the 27-month study period were calculated. Twenty-six patients were diagnosed as having CMV retinitis. In 14 of these patients, T cell phenotyping was done within the 3 months preceding diagnosis. The mean CD4+ lymphocyte count for these patients was 15.6 cells/mm3 (range, 2-33/mm3). At 27 months, the percentage of patients developing CMV retinitis with baseline CD4+ lymphocyte counts of 0-50, 51-100, and 101-250 cells/mm3 was 41.9%, 26.3%, and 14.7%, respectively (log-rank test, p = 0.003). The odds ratio for developing CMV retinitis for those with baseline CD4+ lymphocyte counts of 0-50 cells/mm3 compared with those with CD4+ lymphocyte counts of 101-250 cells/mm3 was 4.62 (p = 0.002). Twenty-four patients had CD4+ lymphocyte counts of < or = 50 cells/mm3 for an average of 13.1 months prior to diagnosis. Twenty-two patients had an acquired immune deficiency syndrome (AIDS)-defining illness diagnosed for an average of 18.0 months prior to the onset of retinitis. CMV retinitis is most likely to develop in patients with AIDS when the CD4+ lymphocyte count is < or = 50 cells/mm3.