Diving into the mammalian swamp of respiratory rhythm generation with the bullfrog
Diving into the mammalian swamp of respiratory rhythm generation with the bullfrog
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DOI：
10.1016/j.resp.2015.09.005
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发表时间：
2016-04-01
影响因子：
2.3
通讯作者：
Wilson, Richard J. A.
中科院分区：
文献类型：
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作者：
Baghdadwala, Mufaddal I.;Duchcherer, Maryana;Wilson, Richard J. A.
所有脊椎动物都会产生某种形式的呼吸节律，无论是将水泵过鳃还是使肺部通气。然而，尽管通气对于生存至关重要，但呼吸中枢模式发生器的结构尚未得到解决。在青蛙和哺乳动物中，越来越多的证据表明腹侧呼吸群存在多个爆发产生区域。这些区域共同作用产生呼吸节律。然而，每个区域似乎对于运动行为的不同阶段都至关重要。当分离时，区域还表现出不同的节律能力，并且具有不同的二氧化碳敏感性和药理学特征。有趣的是，在青蛙和大鼠中，分离时具有最强节律能力的区域位于菱形节段 7/8。此外，两个进化枝中的菱形体 4/5 对于控制受 CO2 最强烈调节的运动模式阶段（哺乳动物的呼气和青蛙的肺爆发募集）至关重要。这些关键特征可能表明这些细胞簇起源于至少 4 亿年前的共同祖先。 (C) 2015 Elsevier B.V. 保留所有权利。
All vertebrates produce some form of respiratory rhythm, whether to pump water over gills or ventilate lungs. Yet despite the critical importance of ventilation for survival, the architecture of the respiratory central pattern generator has not been resolved. In frogs and mammals, there is increasing evidence for multiple burst-generating regions in the ventral respiratory group. These regions work together to produce the respiratory rhythm. However, each region appears to be pivotally important to a different phase of the motor act. Regions also exhibit differing rhythmogenic capabilities when isolated and have different CO2 sensitivity and pharmacological profiles. Interestingly, in both frogs and rats the regions with the most robust rhythmogenic capabilities when isolated are located in rhombomeres 7/8. In addition, rhombomeres 4/5 in both clades are critical for controlling phases of the motor pattern most strongly modulated by CO2 (expiration in mammals, and recruitment of lung bursts in frogs). These key signatures may indicate that these cell clusters arose in a common ancestor at least 400 million years ago. (C) 2015 Elsevier B.V. All rights reserved.