Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance
Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance
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DOI：
10.1016/j.canlet.2013.05.033
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发表时间：
2013-08-28
期刊：
影响因子：
9.7
通讯作者：
Gamian, Andrzej
中科院分区：
文献类型：
--
作者：
Krzystek-Korpacka, Malgorzata;Diakowska, Dorota;Gamian, Andrzej
需要替代的结直肠癌（CRC）筛查和监测策略来预先选择侵入性方法的候选人。我们通过对IL-1 β、IL-6、IL-8、FGF-2、G-CSF、GM-CSF、MCP-1、MIP-1 α、TNF-α、VEGF-A、PDGF-B和CEA的多重分析，比较了CRC（n = 99）、健康（n = 98）、高CRC风险状况（n = 48）和明显炎症（n = 69）的全身炎症特征。细胞因子与CRC进展相对应。FGF 2、CM-CSF、IL-1 β、IL-6、MIP-1 α、PDGF-BB、TNF-α和VEGF-A高于已处于I期CRC的对照组，FGF 2、IL-1 β和MIP-1 α也高于CRC高危个体。旨在区分早期CRC与对照、腺瘤或炎症性肠道疾病（IBD）患者的细胞因子组具有良好的准确性，但只有IBD组具有有希望的特异性（95%的灵敏度）。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Alternate colorectal cancer (CRC) screening and surveillance strategies are needed to pre-select candidates for invasive methods. We compared systemic inflammatory profiles in CRC (n = 99), health (n = 98), high CRC-risk conditions (n = 48) and overt inflammation (n = 69) by multiplexed analysis of IL-1 beta, IL-6, IL-8, FGF-2, G-CSF, GM-CSF, MCP-1, MIP-1 alpha, TNF-alpha, VEGF-A, and PDGF-B and CEA. Cytokines corresponded with CRC advancement. FGF2, CM-CSF, IL-1 beta, IL-6, MIP-1 alpha, PDGF-BB, TNF-alpha, and VEGF-A were higher than in controls already in stage I CRC with FGF2, IL1-beta, and MIP-1 alpha higher than in high CRC-risk individuals as well. Cytokine panels devised to differentiate early CRC from controls, adenomas, or inflammatory bowel disease patients (IBD) had good accuracy but only IBD panel had promising specificity at 95% sensitivity. (C) 2013 Elsevier Ireland Ltd. All rights reserved.