Sleep and obesity.
Sleep and obesity.
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DOI：
10.1097/mco.0b013e3283479109
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发表时间：
2011-07
影响因子：
3.1
通讯作者：
Pannain S
中科院分区：
文献类型：
--
作者：
Beccuti G;Pannain S
这篇综述总结了睡眠时间减少和睡眠质量差与肥胖相关的最新证据，重点是成年人的研究。已发表和未发表的健康检查调查和流行病学研究表明，自1980年以来，全世界肥胖症的流行率翻了一番。2008年，每10个成年人中就有1个肥胖，女性比男性更容易肥胖。这种肥胖流行病已经被睡眠时间减少的趋势所掩盖。睡眠质量差，导致整体睡眠不足也成为经常抱怨的问题。越来越多的实验室和流行病学研究证据表明，睡眠时间短和睡眠质量差是肥胖发展的新风险因素。睡眠是神经内分泌功能和葡萄糖代谢的重要调节剂，并且睡眠不足已被证明会导致代谢和内分泌改变，包括葡萄糖耐量降低、胰岛素敏感性降低、皮质醇夜间浓度增加、生长激素释放肽水平增加、瘦素水平降低以及饥饿感和食欲增加。最近的流行病学和实验室证据证实了先前的研究结果，即睡眠不足与肥胖风险增加之间存在关联。
This review summarizes the most recent evidence linking decreased sleep duration and poor sleep quality to obesity, focusing upon studies in adults. Published and unpublished health examination surveys and epidemiological studies suggest that the worldwide prevalence of obesity has doubled since 1980. In 2008, 1 in 10 adults was obese, with women more likely to be obese than men. This obesity epidemic has been paralleled by a trend of reduced sleep duration. Poor sleep quality, which leads to overall sleep loss has also become a frequent complaint. Growing evidence from both laboratory and epidemiological studies points to short sleep duration and poor sleep quality as new risk factors for the development of obesity. Sleep is an important modulator of neuroendocrine function and glucose metabolism and sleep loss has been shown to result in metabolic and endocrine alterations, including decreased glucose tolerance, decreased insulin sensitivity, increased evening concentrations of cortisol, increased levels of ghrelin, decreased levels of leptin, and increased hunger and appetite. Recent epidemiological and laboratory evidence confirm previous findings of an association between sleep loss and increased risk of obesity.