Antimicrobial Constituents of the Mature Carpels of Manglietiastrum sinicum.
Antimicrobial Constituents of the Mature Carpels of Manglietiastrum sinicum.
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DOI：
10.1021/np500187c
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发表时间：
2014-08
影响因子：
5.1
通讯作者：
Jia-Yin Ding;C. Yuan;Ming-Ming Cao-Ming;Wei-Wei Liu-Wei;Chun Yu;Hai-Yuan Zhang;Yu Zhang;Y. Di;Hong-ping He;Shun-Lin Li;X. Hao
中科院分区：
文献类型：
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作者：
Jia-Yin Ding;C. Yuan;Ming-Ming Cao-Ming;Wei-Wei Liu-Wei;Chun Yu;Hai-Yuan Zhang;Yu Zhang;Y. Di;Hong-ping He;Shun-Lin Li;X. Hao
从中华木莲（Manglietiastrum sinicum）的成熟心皮中分得7个新化合物，包括1个优泊二烯酮型木脂素（1）、1个二苯并环辛二烯型木脂素（2）、3个四氢呋喃型木脂素（3-5）和2个苯甲酸1-苯基丁酯（6，7），以及6个已知化合物。新化合物1-7的结构经光谱技术确定，其中芒果素A（1）的绝对构型经X-射线晶体学测定。化合物1-4对金黄色葡萄球菌、MRSA 82（#）、MRSA 92（#）、MRSA 98（#）和MRSA 331（#）表现出中等的抗微生物活性（MIC值：0.016-0.14 μM）。化合物2和3对5种人肿瘤细胞株均表现出较弱的细胞毒活性。
Seven new compounds, including a eupodienone-type lignan (1), a dibenzocyclooctadiene-type lignan (2), three tetrahydrofuran-type lignans (3-5), and two 1-phenylbutyl benzoates (6, 7), together with six known compounds, were isolated from the mature carpels of Manglietiastrum sinicum. The structures of new compounds 1-7 were defined by spectroscopic techniques, and the absolute configuration of manglisin A (1) was determined by X-ray crystallography. Compounds 1-4 exhibited moderate antimicrobial activities (MIC values: 0.016-0.14 μM) against Staphylococcus aureus, MRSA 82(#), MRSA 92(#), MRSA 98(#), and MRSA 331(#). Compounds 2 and 3 showed weak cytotoxic activity against five human tumor cell lines.