Autologous bone marrow mononuclear cell implantation induces angiogenesis and bone regeneration in a patient with compartment syndrome.
Autologous bone marrow mononuclear cell implantation induces angiogenesis and bone regeneration in a patient with compartment syndrome.
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DOI：
10.1253/circj.70.1362
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发表时间：
2006-09
期刊：
影响因子：
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通讯作者：
Takashi Umemura;K. Nishioka;A. Igarashi;Y. Kato;M. Ochi;K. Chayama;M. Yoshizumi;Y. Higashi
中科院分区：
文献类型：
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作者：
Takashi Umemura;K. Nishioka;A. Igarashi;Y. Kato;M. Ochi;K. Chayama;M. Yoshizumi;Y. Higashi
一名 28 岁男子因胫骨和腓骨骨折，右小腿出现骨筋膜室综合征。尽管进行了筋膜切开术，但许多动脉塌陷，胫骨和腓骨骨折并未愈合。进行自体骨髓单核细胞（BMMNC）植入以治疗性血管生成和随后的骨再生，4周后，血管造影显示胫骨骨折周围的侧支血管明显增加，6个月后完成愈合。 BMMNC 植入疗法可能为筋膜室综合征患者提供治疗性血管生成和成骨作用。
A 28-year-old man developed compartment syndrome in the right lower leg after fracture of the tibia and fibula. Despite fasciotomy, many arteries collapsed and union of the tibial and fibula fractures did not occur. Autologous bone marrow mononuclear cell (BMMNC) implantation for therapeutic angiogenesis and subsequent bone regeneration was performed and 4 weeks later, angiography showed a marked increase in collateral vessels surrounding the tibial fracture, and union was completed 6 months later. BMMNC implantation therapy might provide therapeutic angiogenesis and osteogensis in patients with compartment syndrome.