No association between residential exposure to petrochemicals and brain tumor risk.
No association between residential exposure to petrochemicals and brain tumor risk.
复制标题
居住地接触石化产品与脑肿瘤风险之间没有关联。
DOI：
10.1158/1055-9965.epi-05-0594
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Christiani,DavidC
中科院分区：
文献类型：
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作者：
Yu,Chu-Ling;Wang,Su-Fen;Pan,Pi-Chen;Wu,Ming-Tsang;Ho,Chi-Kung;Smith,ThomasJ;Li,Yi;Pothier,LucilleJ;Christiani,DavidC
材料和方法研究设计关于我们研究设计的细节（病例组，n= 143;对照组，n= 364）在前面已经描述过（6，7）。简单地说，这是一项在台湾南部高雄都会区进行的基于人群的病例对照研究，排除农村地区，以避免农药暴露的潜在混杂效应。研究面积为1657.1平方公里。研究区有四个石化工业联合体，生产从上游到下游的各种石油化工产品。受试者于1997年11月至2003年6月期间招募。符合条件的病例包括所有经病理证实的原发性脑肿瘤病例（良性和恶性：国际疾病分类-9个代码，191-192，194.3-194.4和225），年龄为0至29岁，目前居住在研究区域。对照组为研究地区无癌症的现有居民，他们是根据台湾政府的个人身份证号码系统从人口登记数据中随机选择的。每例病例与3名年龄（±1岁）和性别相匹配的对照。与父母和/或受试者进行面对面访谈，以收集有关描述性特征、居住史、病史以及环境、职业和行为因素的信息。
Materials and MethodsStudy designDetails regarding the design of our study (cases, n= 143; controls, n= 364) were described previously (6, 7). Briefly, this is a population-based case-control study conducted in the metropolitan area of Kaohsiung, southern Taiwan, excluding the rural areas to avoid the potential confounding effects from pesticide exposure. The study area is∼ 657.1 km 2. There are four petrochemical industrial complexes in the study area, producing various products from upstream to downstream petrochemicals. Subjects were recruited between November 1997 and June 2003. Eligible cases included all pathologically confirmed incident primary brain tumor cases (benign and malignant: International Classification of Diseases-9 codes, 191-192, 194.3-194.4, and 225) ages 0 to 29 years and currently residing in the study area. Controls were cancer-free current residents of the study area, selected randomly from the population registry data based on the personal identification number system of the Taiwanese government. Each case was matched with three controls on age (±1 year) and sex. In-person interviews were conducted with the parents and/or subjects to collect information regarding descriptive characteristics, residential history, medical history, as well as environmental, occupational, and behavioral factors.