Immunohistochemical assessment of apoptosis-associated proteins: p53, Bcl-xL, Bax and Bak in gastric cancer cells in correlation with clinical and pathomorphological factors
Immunohistochemical assessment of apoptosis-associated proteins: p53, Bcl-xL, Bax and Bak in gastric cancer cells in correlation with clinical and pathomorphological factors
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DOI：
10.2478/v10039-012-0012-z
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发表时间：
2012-06-01
影响因子：
2.7
通讯作者：
Kedra, B.
中科院分区：
文献类型：
--
作者：
Gryko, M.;Pryczynicz, A.;Kedra, B.
目的：p53蛋白与Bcl-2家族蛋白Bax、巴克、Bcl-xL共同调控细胞凋亡。本研究的目的是分析p53，巴克，Bcl-xL和Bax的表达在胃癌和健康胃mucosa.Material和方法：研究组包括66例胃癌，手术治疗的第二部门的一般和胃肠外科，比亚韦斯托克医科大学。结果：与正常胃粘膜相比，胃癌组织中蛋白质的表达有显著性差异。p53和Bax在癌细胞中的表达显著高于正常粘膜（70%vs13%，50%vs13%），而巴克和Bcl-xL的表达显著低于正常粘膜（18%vs83%，74%vs97%）（p
Purpose: The p53 protein as well as Bcl-2 family proteins such as Bax, Bak and Bcl-xL regulate apoptosis. The study objective was to analyze the expression of p53, Bak, Bcl-xL and Bax in gastric cancer and in healthy gastric mucosa.Material and Methods: The study group consisted of 66 patients with gastric cancer, treated surgically in II Department of General and Gastroenterological Surgery, Medical University of Bialystok. The expression of the studied proteins was assessed using the immunohistochemical method.Results: Significant differences were found in the expressions of the studied proteins as compared to healthy gastric mucosa. The expressions of p53 and Bax were significantly higher (70% vs 13% and 50% vs 13%), whereas those of Bak and Bcl-xL significantly lower (18% vs 83% and 74% vs 97%) in cancer cells than in normal mucosa (p