Expression of p53 during mouse embryogenesis.
Expression of p53 during mouse embryogenesis.
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发表时间：
1991-11
期刊：
影响因子：
4.6
通讯作者：
P. Schmid;A. Lorenz;H. Hameister;M. Montenarh
中科院分区：
文献类型：
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作者：
P. Schmid;A. Lorenz;H. Hameister;M. Montenarh
用原位杂交法检测了小鼠胚胎发育过程中P53蛋白的表达，时间为8.5天至18.5天(P.C.)。在第8.5天的所有细胞中均检测到高水平的P53基因。晚上10点5分。小鼠胚胎。然而，在发育后期，在特定组织的分化过程中，例如脑、肝、肺、胸腺、肠、唾液腺和肾脏的表达变得更加明显。在终末分化的细胞中，P53基因的表达水平明显下降。在大脑中，在有丝分裂后但尚未终末分化的细胞中也观察到杂交信号。因此，P53的基因表达似乎与该器官中的细胞增殖无关。对P53在细胞分化中的作用进行了讨论。
By in situ hybridisation we have examined the expression of p53 during mouse embryogenesis from day 8.5 to day 18.5 post coitum (p.c.). High levels of p53 mRNA were detected in all cells of the day 8.5 p.c. and 10.5 p.c. mouse embryo. However, at later stages of development, expression became more pronounced during differentiation of specific tissues e.g. of the brain, liver, lung, thymus, intestine, salivary gland and kidney. In cells undergoing terminal differentiation, the level of p53 mRNA declined strongly. In the brain, hybridisation signals were also observed in postmitotic but not yet terminally differentiated cells. Therefore, gene expression of p53 does not appear to be linked with cellular proliferation in this organ. A proposed role for p53 in cellular differentiation is discussed.