Forkhead box transcription factor, forkhead box A1, shows negative association with lymph node status in endometrial cancer, and represses cell proliferation and migration of endometrial cancer cells
Forkhead box transcription factor, forkhead box A1, shows negative association with lymph node status in endometrial cancer, and represses cell proliferation and migration of endometrial cancer cells
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DOI：
10.1111/j.1349-7006.2012.02201.x
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发表时间：
2012-04-01
期刊：
影响因子：
5.7
通讯作者：
Inoue, Satoshi
中科院分区：
文献类型：
--
作者：
Abe, Yayoi;Ijichi, Nobuhiro;Inoue, Satoshi
子宫内膜癌是女性生殖道最常见的恶性肿瘤，预后差。它主要是一种由类固醇激素（包括雌激素和孕激素）调节的激素依赖性癌症。叉头盒A1（FOXA 1）是叉头盒转录因子家族的成员，在雌激素受体（ER）阳性乳腺癌中起先锋因子的作用。在本研究中，我们研究FOXA 1在子宫内膜癌的表达免疫组化分析。109例中有40例（37%）检测到FOXA 1的核免疫反应性，并发现与淋巴结状态呈负相关（P = 0.033）。在ER阳性石川子宫内膜癌细胞中，小干扰RNA介导的FOXA 1下调促进细胞增殖和迁移。此外，外源性引入FOXA 1抑制石川细胞的增殖和迁移。这些结果表明FOXA 1通过调节子宫内膜癌细胞的增殖和迁移作为肿瘤抑制因子发挥作用。（Cancer Sci 2012; 103：806812）
Endometrial cancer is the most common malignancy of the female genital tract and is associated with poor prognosis. It is primarily a hormone-dependent cancer that is regulated by steroid hormones, including estrogen and progesterone. Forkhead box A1 (FOXA1) is a member of the forkhead box transcription factor family and functions as a pioneer factor in estrogen receptor (ER)-positive breast cancer. In the present study, we investigated the expression of FOXA1 in endometrial cancers by immunohistochemical analysis. Nuclear immunoreactivity for FOXA1 was detected in 40 of 109 cases (37%), and was found to be negatively associated with lymph node status (P = 0.033). In ER-positive Ishikawa endometrial cancer cells, small interfering RNA-mediated downregulation of FOXA1 promoted cell proliferation and migration. Furthermore, exogenously introduced FOXA1 suppressed both proliferation and migration of Ishikawa cells. These results suggest that FOXA1 functions as a tumor suppressor through modulation of proliferation and migration of endometrial cancer cells. (Cancer Sci 2012; 103: 806812)