Stimulated Raman Scattering: From Bulk to Nano.
Stimulated Raman Scattering: From Bulk to Nano.
复制标题
DOI：
10.1021/acs.chemrev.6b00545
复制
发表时间：
2017-04-12
期刊：
影响因子：
62.1
通讯作者：
Potma EO
中科院分区：
文献类型：
--
作者：
Prince RC;Frontiera RR;Potma EO
受激拉曼散射（SRS）描述了在20世纪60年代首次发现和发展的一系列技术。尽管该技术的早期历史与激光光源的历史相似，但最近的进展已经刺激了它在科学领域和空间尺度上的使用和发展的复苏。SRS是一种非线性技术，用于探测与自发拉曼散射相同的分子振动模式。自发拉曼散射是一种非相干技术，而SRS是一种相干过程，这一事实提供了比传统拉曼技术更强的信号和时间分辨振动运动的能力。脉冲产生和探测策略的技术改进使SRS能够探测越来越小的体积和更短的时间尺度。这使得SRS研究从最初的探测大量介质的领域，发展到在微观尺度上对生物组织和单细胞进行成像，并最终在纳米尺度上以亚衍射分辨率表征样品。在这篇综述中，我们概述了该技术的历史，概述了其基本特性，并介绍了历史和当前在多个长度尺度上的应用，以强调SRS在分子科学中的应用。
Stimulated Raman scattering (SRS) describes a family of techniques first discovered and developed in the 1960s. Whereas the nascent history of the technique is parallel to that of laser light sources, recent advances have spurred a resurgence in its use and development that has spanned across scientific fields and spatial scales. SRS is a nonlinear technique that probes the same vibrational modes of molecules that are seen in spontaneous Raman scattering. While spontaneous Raman scattering is an incoherent technique, SRS is a coherent process, and this fact provides several advantages over conventional Raman techniques, among which are much stronger signals and the ability to time-resolve the vibrational motions. Technological improvements in pulse generation and detection strategies have allowed SRS to probe increasingly smaller volumes and shorter time scales. This has enabled SRS research to move from its original domain, of probing bulk media, to imaging biological tissues and single cells at the micro scale, and, ultimately, to characterizing samples with subdiffraction resolution at the nanoscale. In this Review, we give an overview of the history of the technique, outline its basic properties, and present historical and current uses at multiple length scales to underline the utility of SRS to the molecular sciences.