Development of dual anti-biofilm and anti-bacterial medical devices
Development of dual anti-biofilm and anti-bacterial medical devices
复制标题
DOI：
10.1039/d0bm00709a
复制
发表时间：
2020-07-21
影响因子：
6.6
通讯作者：
Hook, Andrew L.
中科院分区：
文献类型：
--
作者：
Burroughs, Laurence;Ashraf, Waheed;Hook, Andrew L.
The rising occurrence of antimicrobial resistance demands new strategies for delivering antibiotics to ensure their effective use. In this study, a multi-functional strategy to address medical device associated infections is explored whereby an anti-attachment and an antibacterial mechanism have been combined. Silicone catheters impregnated with multiple antibiotics are coated with polyacrylate coatings previously shown to reduce bacterial attachment and biofilm formation. Antibiotics are delivered through the applied coating and the delivery rate depends on the coating thickness and the calculated logP. Coated devices achieve a zone of inhibition and TK100 to Gram-negativeEscherichia coliand Gram-positiveStaphylococcus aureus similarto those of uncoated devices, whilst maintaining anti-attachment properties. No adverse immunological responses of the coatings were observed. The multi-functional nature of the device developed in the study represents an important approach to combatting medical device associated infections.
