The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans
The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans
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DOI：
10.1126/science.1103773
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发表时间：
2005-02-25
期刊：
影响因子：
56.9
通讯作者：
Hyman, RW
中科院分区：
文献类型：
--
作者：
Loftus, BJ;Fung, E;Hyman, RW
新生隐球菌是一种广泛存在于环境中的担子酵母，是真菌致病的模型，也是一种具有全球重要性的机会人类病原体。我们已经对其类似于2000万碱基的基因组进行了测序，该基因组包含类似于6500个富含内含子的基因结构，并编码了一个转录组，其中含有丰富的选择性剪接和反义信息。基因组中含有丰富的转座子，其中许多转座子聚集在候选着丝粒区域。这些转座子的存在可能导致核型不稳定和表型变异。新生链球菌编码独特的基因，这些基因可能有助于其不同寻常的毒力特性，比较两个表型不同的菌株发现，除了基因组之间的序列多态外，基因含量也存在差异。
Cryptococcus neoformans is a basidionnycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its similar to20-megabase genome, which contains similar to6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.