Dynamics of dengue virus circulation: a silent epidemic in a complex urban area
Dynamics of dengue virus circulation: a silent epidemic in a complex urban area
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DOI：
10.1046/j.1365-3156.2002.00930.x
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发表时间：
2002-09-01
影响因子：
3.3
通讯作者：
Cairncross, S
中科院分区：
文献类型：
--
作者：
Teixeira, MD;Barreto, ML;Cairncross, S
在过去15年中，巴西大部分地区报告了登革1型和登革2型血清型，登革3型血清型最近才被发现。这项前瞻性研究是在巴西东北部大城市萨尔瓦多进行的，那里以前记录过两次流行病（DEN-1和DEN-2）。我们获得了萨尔瓦多30个采样地区人群中登革热感染的血清阳性率和1年发病率，并分析了病毒传播强度、生活水平和媒介密度之间的关系。其中一种或两种流行血清型（DEN-1和DEN-2）感染的血清阳性率（68.7%）和年发病率（70.6%）较高。在所有研究地区，从社会经济地位最高的地区到最低的地区，都观察到高传播率。埃及伊蚊平均PI（前提指数）为7.4%（0.27 ~ 25.6%）。即使在PI最低的地区（小于或等于3%），血清发病率也高达54.6%。这些调查结果突出表明，在卫生部门认为流行率较低的时期，存在一种无声的流行病，表明了登革热在萨尔瓦多市传播的强度和速度。
Serotypes of dengue DEN-1 and DEN-2 have been reported in much of Brazil over the last 15 years, and DEN-3 serotype was only recently detected. This prospective study was conducted in Salvador, a large city in north-east Brazil, where two epidemics were previously recorded (DEN-1 and DEN-2). We obtained the seroprevalence and 1-year incidence of dengue infections in the population of 30 sampling areas of Salvador and analysed the relationship between intensity of viral circulation, standard of living and vector density. High seroprevalence (68.7%) and annual incidence (70.6%) of infection for one or both circulating serotypes (DEN-1 and DEN-2) were found. High rates of transmission were observed in all studied areas, from the highest to the lowest socio-economic status. The mean PI (Premise Index) for Aedes aegypti was 7.4% (range 0.27-25.6%). Even in the areas with the lowest PI (less than or equal to3%) the observed seroincidence was 54.6%. These findings highlighted the existence of a silent epidemic during a period perceived by the Health Services as of low endemicity, indicating the strength and speed of dengue transmission in the city of Salvador.