Sympathoexcitation to intravenous interleukin-1beta is dependent on forebrain neural circuits.
Sympathoexcitation to intravenous interleukin-1beta is dependent on forebrain neural circuits.
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静脉注射白介素-1β 的交感神经兴奋依赖于前脑神经回路。
DOI：
10.1152/ajpheart.00181.2002
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Fels,RichardJ
中科院分区：
文献类型：
--
作者：
Kenney,MichaelJ;Blecha,Frank;Wang,Yan;McMurphy,Rose;Fels,RichardJ
We investigated the contributions of forebrain, brain stem, and spinal neural circuits to interleukin (IL)-1β-induced sympathetic nerve discharge (SND) responses in α-chloralose-anesthetized rats. Lumbar and splenic SND responses were determined in spinal cord-transected (first cervical vertebra, C1), midbrain-transected (superior colliculus), and sham-transected rats before and for 60 min after intravenous IL-1β (285 ng/kg). The observations made were the following:1) lumbar and splenic SND were significantly increased after IL-1β in sham C1-transected rats but were unchanged after IL-1β in C1-transected rats;2) intrathecal administration ofdl-homocysteic acid (10 ng) increased SND in C1-transected rats;3) lumbar and splenic SND were significantly increased after IL-1β in sham- but not midbrain-transected rats; and4) midbrain transection did not alter the pattern of lumbar and splenic SND, demonstrating the integrity of brain stem sympathetic neural circuits after decerebration. These results demonstrate that an intact forebrain is required for mediating lumbar and splenic sympathoexcitatory responses to intravenous IL-1β, thereby providing new information about the organization of neural circuits responsible for mediating sympathetic-immune interactions.
