Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with 152Tb-DOTATOC
Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with 152Tb-DOTATOC
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DOI：
10.1039/c7dt01936j
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发表时间：
2017-11-14
影响因子：
4
通讯作者：
Mueller, Cristina
中科院分区：
文献类型：
--
作者：
Baum, Richard P.;Singh, Aviral;Mueller, Cristina
The existence of theragnostic pairs of radionuclides allows the preparation of radiopharmaceuticals for diagnostic and therapeutic purposes. Radiolanthanides, such as Lu-177, are successfully used for therapeutic purposes; however, a perfect diagnostic match is currently not available for clinical use. A unique, multi-disciplinary study was performed using Tb-152 (T-1/2 = 17.5 h, E beta(+)(average) = 1140 keV, I beta(+) = 20.3%), which resulted in the first-in-human PET/CT images with this promising radionuclide. For this purpose, Tb-152 was produced via a spallation process followed by mass separation at ISOLDE, CERN. The chemical separation and quality control, performed at PSI, resulted in a pure product in sufficient yields. Clinical PET phantom studies revealed an increased image noise level, because of the smaller beta(+) branching ratio of Tb-152 as compared to standard PET nuclides at matched activity concentrations; however, the expected recovery would be comparable at matched signal-to-noise ratios in clinical PET. Tb-152 was used for labeling DOTATOC, at Zentralklinik Bad Berka, and administered to a patient for a first-in-human clinical study. PET scans were performed over a period of 24 h, allowing the visualization of even small metastases with increased tumor-to-background contrast over time. Based on the results obtained in this work, it can be deduced that PET/CT imaging with Tb-152-labeled targeting agents has promise for clinical application and may be particularly interesting for pre-therapeutic dosimetry.
