Beyond acne: Current aspects of sebaceous gland biology and function
Beyond acne: Current aspects of sebaceous gland biology and function
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DOI：
10.1007/s11154-016-9389-5
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发表时间：
2016-10
影响因子：
8.2
通讯作者：
C. Zouboulis;M. Picardo;Q. Ju;I. Kurokawa;D. Törőcsik;T. Bíró;M. Schneider
中科院分区：
文献类型：
--
作者：
C. Zouboulis;M. Picardo;Q. Ju;I. Kurokawa;D. Törőcsik;T. Bíró;M. Schneider
The sebaceous gland is most commonly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland’s central role in acne pathogenesis, early research had focused on its lipogenic activity. Less studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin, and skin aging have only recently attracted the attention of researchers from different disciplines. Here, we summarize recent multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.
