Theoretical model of the relationship between single embryo transfer rate and multiple pregnancy rate in Japan.
Theoretical model of the relationship between single embryo transfer rate and multiple pregnancy rate in Japan.
复制标题
DOI：
10.1155/2012/620753
复制
发表时间：
2012
影响因子：
3.2
通讯作者：
Ooki S
中科院分区：
文献类型：
--
作者：
Ooki S
本研究旨在探讨辅助生殖技术（ART）中单胚胎移植（SET）对降低多胎妊娠率的作用。我们还间接地根据SET扩散估计了单合子（MZ）孪生率。采用2007 - 2009年日本全国SET数据，假设并检验了反向S形曲线。多胎妊娠率几乎呈线性下降，其中SET妊娠率在回归近似值的40%至80%之间。线性近似法高估了早期多胎妊娠率，低估了晚期多胎妊娠率。多胎妊娠率在早期受ART总妊娠率提高的影响，在晚期受SET后MZ双胎的影响。SET后估计的MZ孪生率约为2%。
The purpose of the present study was to examine the effect of single embryo transfer (SET) in assisted reproductive technology (ART) on the reduction of the multiple pregnancy rate. We also estimated the monozygotic (MZ) twinning rates according to the SET diffusion indirectly. A reverse sigmoid curve was assumed and examined using nationwide data of SET from 2007 to 2009 in Japan. The multiple pregnancy rate decreased almost linearly where the SET pregnancy rate was between about 40% and 80% of regression approximation. The linear approximation overestimated multiple pregnancy rates in an early period and underestimated multiple pregnancy rates in the final period. The multiple pregnancy rate seemed to be influenced by the improvement of the total pregnancy rate of ART in the early period and by the MZ twinning after SET in the final period. The estimated MZ twinning rate after SET was around 2%.