Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort
Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort
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DOI：
10.1378/chest.126.4.1071
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发表时间：
2004-10-01
期刊：
影响因子：
9.6
通讯作者：
Kinney, PL
中科院分区：
文献类型：
--
作者：
Miller, RL;Garfinkel, R;Kinney, PL
研究目的：几项研究发现柴油暴露、呼吸道症状和/或肺功能受损之间存在相关性。我们假设，产前暴露于空气中的多环芳烃（PAH），柴油机废气和其他燃烧源的重要组成部分，可能与幼儿的呼吸道症状。我们还假设暴露于环境烟草烟雾（ETS）可能会使症状恶化，超出观察到的与PAH单独相关的症状。设计/参与者：为了验证我们的假设，我们招募了303名来自北方曼哈顿的孕妇，这些孕妇被认为是暴露于PAH和ETS的高风险，收集了48小时的个人PAH暴露测量值，并前瞻性地监测了她们的孩子。到12个月大时，出生前暴露于PAH并出生后暴露于ETS的儿童中报告的咳嗽和喘息更多（PAH X ETS相互作用比值比[OR]分别为1.41 [p < 0.01]和1.29 [p < 0.05]）。出生后24个月时，出生前暴露于PAH和ETS的儿童更常报告呼吸困难和可能的哮喘（PAR X ETS OR分别为1.54和1.64 [p < 0.05]）。结论：我们的研究结果表明，早期暴露于空气中的PAH和ETS可导致12至24个月时呼吸道症状增加和可能的哮喘。降低生活在内城的幼儿患呼吸道疾病风险的干预措施可能需要解决多种环境暴露的重要性。
Study objectives: Several studies have found associations between diesel exposure, respiratory symptoms, and/or impaired pulmonary function. We hypothesized that prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAH), important components of diesel exhaust and other combustion sources, may be associated with respiratory symptoms in young children. We also hypothesized that exposure to environmental tobacco smoke (ETS) may worsen symptoms beyond that observed to be associated with PAH alone.Design/participants: To test our hypotheses, we recruited 303 pregnant women from northern Manhattan believed to be at high risk for exposure to both PAH and ETS, collected 48-h personal PAH exposure measurements, and monitored their children prospectively.Results: By 12 months of age, more cough and wheeze were reported in children exposed to prenatal PAH in concert with ETS postnatally (PAH X ETS interaction odds ratios [ORs], 1.41 [p < 0.01] and 1.29 [p < 0.05], respectively). By 24 months, difficulty breathing and probable asthma were reported more frequently among children exposed to prenatal PAH and ETS postnatally (PAR X ETS ORs, 1.54 and 1.64, respectively [p < 0.05]).Conclusions: Our results suggest that early exposure to airborne PAH and ETS can lead to increased respiratory symptoms and probable asthma by age 12 to 24 months. Interventions to lower the risk of respiratory disease in young children living in the inner city may need to address the importance of multiple environmental exposures.