Ultrastructural studies of neurons and synapses in the visual system of amblyopic cats
Ultrastructural studies of neurons and synapses in the visual system of amblyopic cats
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发表时间：
1994
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通讯作者：
Shao Lg;Zhang Yh;Zhang Dg
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作者：
Shao Lg;Zhang Yh;Zhang Dg
14只2-4周龄的小猫随机分为正常组（N）和单眼剥夺组（MD）。在确认弱视发生后，在通过眼睑修补术进行单眼剥夺之前和之后 12 周进行了 PVEP 测试。透射电镜下观察MD眼和N眼的视网膜中央神经节细胞、同侧膝状核层、视皮层17区IV层神经元以及神经突触，发现MD眼存在不同程度的萎缩和退行性改变，支持作者认为弱视的功能改变是基于亚细胞病理学的，出生后视觉障碍导致视觉系统的组织病理学损伤。
14 kittens of 2-4 weeks were randomly divided into normal (N) and monocular deprivation (MD) groups. PVEP was tested before and after monocular deprivation by blepharorrhaphy for 12 weeks, when development of amblyopia was confirmed. Under TEM, the central retinal ganglion cells, the ipsilateral geniculate nucleus layers, the neurons of layer IV of visual cortex area 17, and the neural synapses of MD and N eyes were examined to find that atrophic and degenerative changes to various degrees existed in the MD eyes, supporting the authors belief that the functional changes in amblyopia were based on subcellular pathology, and visual disorders after birth resulted in histopathological injuries to the visual system.