GPCRTree: online hierarchical classification of GPCR function.
GPCRTree: online hierarchical classification of GPCR function.
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DOI：
10.1186/1756-0500-1-67
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发表时间：
2008-08-21
影响因子：
1.8
通讯作者：
Flower DR
中科院分区：
文献类型：
--
作者：
Davies MN;Secker A;Halling-Brown M;Moss DS;Freitas AA;Timmis J;Clark E;Flower DR
G蛋白偶联受体（gpcr）在将细胞外信号转导到细胞内反应中发挥着重要的生理作用。大约50%的上市药物靶向GPCR。从其初级序列有效预测GPCR的功能仍然有相当大的兴趣。利用从数据挖掘和蛋白质化学计量学中提取的技术，设计了一种无比对的GPCR分类方法。它使用蛋白质物理性质的简单表示。GPCRTree是一个公开的互联网服务器，它实现了一种算法，可以在类、子家族和子家族级别对GPCRs进行分类。一个选择性的自上而下的分类器被开发，分配序列在GPCR层次结构。与其他公开可用的GPCR预测服务器相比，GPCRTree在每个分类级别上都要准确得多。该服务器已于2008年3月上线，网址为：。
G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR. There remains considerable interest in effectively predicting the function of a GPCR from its primary sequence. Using techniques drawn from data mining and proteochemometrics, an alignment-free approach to GPCR classification has been devised. It uses a simple representation of a protein's physical properties. GPCRTree, a publicly-available internet server, implements an algorithm that classifies GPCRs at the class, sub-family and sub-subfamily level. A selective top-down classifier was developed which assigns sequences within a GPCR hierarchy. Compared to other publicly available GPCR prediction servers, GPCRTree is considerably more accurate at every level of classification. The server has been available online since March 2008 at URL: .