Hemodynamic, echocardiographic, and exercise-related effects of the HeartWare left ventricular assist device in advanced heart failure.
Hemodynamic, echocardiographic, and exercise-related effects of the HeartWare left ventricular assist device in advanced heart failure.
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DOI：
10.1111/j.1751-7133.2012.00302.x
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发表时间：
2013-01-01
期刊：
影响因子：
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通讯作者：
MacGowan, Guy A
中科院分区：
文献类型：
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作者：
McDiarmid, Adam;Gordon, Brian;MacGowan, Guy A
这项研究的目的是确定哈特威尔左心辅助装置(哈特威尔国际公司，马萨诸塞州弗雷明翰)对血流动力学、心功能和运动能力的影响。在2009年7月至2011年3月期间，46名晚期心力衰竭患者植入了HVAD。在这些患者中，有30人随后进行了移植评估，这些患者组成了研究队列。30例患者平均评估时间为201±86天，13例患者再次评估时间为351±86天。在两项评估中，血流动力学和运动能力均有显著改善，右心和左心充盈压显著降低；心脏指数、纽约心脏协会分级和最大运动耗氧量增加；肺血管阻力降低(P均<0.05)。
The aim of this study was to determine the effects of the HeartWare left ventricular assist device (HVAD) (HeartWare International, Inc, Framingham, MA) on hemodynamics, ventricular function, and exercise capacity. Between July 2009 and March 2011, 46 patients with advanced heart failure had implantation of the HVAD. Of these patients, 30 had subsequent assessments for transplantation and these patients formed the study cohort. Thirty patients had assessments at a mean of 201±86 days and 13 went on to have a second assessment at 351±86 days. There were marked improvements in hemodynamics and exercise capacity at both assessments, with significant decreases in right and left heart filling pressures; increases in cardiac index, New York Heart Association class, and peak exercise oxygen consumption; and reduction in pulmonary vascular resistance (all P