Human fronto-mesolimbic networks guide decisions about charitable donation
Human fronto-mesolimbic networks guide decisions about charitable donation
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DOI：
10.1073/pnas.0604475103
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发表时间：
2006-10-17
影响因子：
11.1
通讯作者：
Grafman, Jordan
中科院分区：
文献类型：
--
作者：
Moll, Jorge;Krueger, Frank;Grafman, Jordan
人类经常牺牲物质利益来支持或反对基于道德信仰的社会事业。慈善捐赠行为是这一能力在当代的突出表现，也是近年来实验经济学研究的对象。然而，人类利他主义这一独特方面的神经基础仍然不清楚，它超越了人际交往。在这篇文章中，我们使用功能磁共振成像，而参与者匿名捐赠或反对真实的慈善组织有关的主要社会原因。我们发现，中脑边缘奖励系统参与捐赠的方式与获得金钱奖励的方式相同。此外，内侧眶额-膝下区和外侧眶额区在社会依恋和厌恶的更原始机制中也起着关键作用，它们专门介导捐赠或反对社会事业的决定。值得注意的是，当利他主义的选择压倒自私的物质利益时，前额叶皮层的前部会明显地被招募。
Humans often sacrifice material benefits to endorse or to oppose societal causes based on moral beliefs. Charitable donation behavior, which has been the target of recent experimental economics studies, is an outstanding contemporary manifestation of this ability. Yet the neural bases of this unique aspect of human altruism, which extends beyond interpersonal interactions, remain obscure. In this article, we use functional magnetic resonance imaging while participants anonymously donated to or opposed real charitable organizations related to major societal causes. We show that the mesolimbic reward system is engaged by donations in the same way as when monetary rewards are obtained. Furthermore, medial orbitofrontal-subgenual and lateral orbitofrontal areas, which also play key roles in more primitive mechanisms of social attachment and aversion, specifically mediate decisions to donate or to oppose societal causes. Remarkably, more anterior sectors of the prefrontal cortex are distinctively recruited when altruistic choices prevail over selfish material interests.