Ultrastructural and cytochemical studies of melanogenesis in melanocytes of normal human hair matrix.
Ultrastructural and cytochemical studies of melanogenesis in melanocytes of normal human hair matrix.
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正常人毛发基质黑素细胞中黑素生成的超微结构和细胞化学研究。
DOI：
10.1093/oxfordjournals.jmicro.a049773
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
A. Kukita
中科院分区：
文献类型：
--
作者：
K. Jimbow;M. Takahashi;S. Sato;A. Kukita
采用超微结构和细胞化学相结合的方法，探讨了正常人毛发基质黑色素细胞色素颗粒的来源和形成模式。本研究提出了色素颗粒形成的过程。富含酪氨酸酶的蛋白质物质在核糖体上合成，聚集并集中在高尔基体池的外围部分。然后它们被包装成无定形或片状结构，并从扩张的池中出芽分泌到细胞质中。正常人毛发基质黑素细胞中最早的黑素前体在高尔基区不是小的囊泡，而是大的球形液泡。
Combined ultrastructural and cytochemical studies were made to elucidate the origin and the mode of formation of pigment granules in the melanocytes of normal human hair matrix. The present study suggested the following processes of pigment granule formation. The proteinaceous material, rich in tyrosinase and synthesized at the ribosomes, are aggregated and concentrated in the peripheral part of cisternae of Golgi apparatus. They are then packaged into the amorphous or lamellarstructures and secreted into the cytoplasm by budding off from the dilated cisternae. The earliest premelanosomes in the melanocyte of normal human hair matrix are recognizable not as small vesicles but as large spherical vacuoles in the Golgi region.