EFFECTS OF 1-ALPHA-HYDROXYVITAMIN-D3, 1,25-DIHYDROXYVITAMIN-D3, 1,24,25-TRIHYDROXYVITAMIN-D3, AND 1,25,26-TRIHYDROXYVITAMIN-D3 ON MINERAL METABOLISM AND 1,25-DIHYDROXYVITAMIN-D CONCENTRATIONS IN DAIRY-COWS
EFFECTS OF 1-ALPHA-HYDROXYVITAMIN-D3, 1,25-DIHYDROXYVITAMIN-D3, 1,24,25-TRIHYDROXYVITAMIN-D3, AND 1,25,26-TRIHYDROXYVITAMIN-D3 ON MINERAL METABOLISM AND 1,25-DIHYDROXYVITAMIN-D CONCENTRATIONS IN DAIRY-COWS
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DOI：
10.3168/jds.s0022-0302(83)81753-6
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发表时间：
1983-01-01
影响因子：
3.5
通讯作者：
LITTLEDIKE, ET
中科院分区：
文献类型：
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作者：
HOVE, K;HORST, RL;LITTLEDIKE, ET
用5只1-α-葡聚糖处理6只成熟的、非泌乳的、非妊娠的泽西奶牛。维生素D3的羟基化代谢物，以比较代谢物的相对效力。血浆1，25-二羟维生素D在0.05时达到峰值。i.m.后12小时1000 pg/ml注射500 μ g 1，25-二羟基维生素D3，但在3-4天内恢复到注射前浓度。施用500 μ g 1-α-羟维生素D3肌内注射导致1，25-二羟维生素D浓度在处理后48小时逐渐增加至500 pg/ml。当500 μ g的1，25-二羟基维生素D3或1-α-羟基维生素D3口服给药时，血浆1，25-二羟基维生素D峰值为200和100 pg/ml。经口给药后峰浓度的下降速度慢于i.m.给药后。治疗血浆钙增加了20-30%，持续一周或更长时间，这取决于血浆中1，25-二羟维生素D的浓度。所有治疗均导致钙尿症。用1或3个剂量的1，24（R），25-三羟基维生素D3或1，25，26-三羟基维生素D3的两种碳-25立体异构体治疗诱导血浆矿物质的变化较小且持续时间较短。根据这些标准，三羟基维生素D3代谢物在奶牛中的效力仅为1，25-二羟基维生素D3的1/10。都是1. alpha测试的维生素D3的羟基化代谢物影响奶牛的矿物质代谢。口服维生素D3代谢物可能是胃肠外治疗的有用替代方案。
Six mature, nonlactating, nonpregnant Jersey cows were treated with 5 1-.alpha.-hydroxylated metabolites of vitamin D3 to compare relative potencies of the metabolites. Blood plasma 1,25-dihydroxyvitamin D peaked at .apprx. 1000 pg/ml 12 h after i.m. injection of 500 .mu.g 1,25-dihydroxyvitamin D3 but returned to preinjection concentration within 3-4 days. Administration of 500 .mu.g 1-.alpha.-hydroxyvitamin D3 i.m. led to a gradual increase in 1,25-dihydroxyvitamin D concentration to 500 pg/ml 48 h after treatment. When 500 .mu.g of 1,25-dihydroxyvitamin D3 or 1-.alpha.-hydroxyvitamin D3 were given orally, plasma 1,25-dihydroxyvitamin D peaked at .apprx. 200 and 100 pg/ml, respectively. The decline from peak concentrations occurred more slowly after oral treatment than after i.m. treatment. Plasma Ca was increased by 20-30% for a week or more, depending on 1,25-dihydroxyvitamin D concentrations in plasma. All treatments resulted in calciuria. Treatment with 1 or 3 doses of 1,24(R),25-trihydroxyvitamin D3 or both carbon-25 stereoisomers of 1,25,26-trihydroxyvitamin D3 induced smaller and less protracted changes in plasma minerals. Based on these criteria, the trihydroxylated vitamin D3 metabolites appeared only 1/10 as potent as 1,25-dihydroxyvitamin D3 in the cow. All 1.alpha.-hydroxylated metabolites of vitamin D3 tested affect mineral metabolism in cows. Oral administration of vitamin D3 metabolites may be a useful alternative to parenteral treatment.