Reticuloendothelial and mesangial function in murine immune complex glomerulonephritis.
Reticuloendothelial and mesangial function in murine immune complex glomerulonephritis.
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小鼠免疫复合物肾小球肾炎的网状内皮和系膜功能。
DOI：
10.1038/ki.1979.20
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发表时间：
1979
影响因子：
19.6
通讯作者：
Saulo Klahr
中科院分区：
文献类型：
--
作者：
P. Hoffsten;Aron Swerdlin;Michael Bartell;Cynthia Hill;Joseph Venverloh;Kurt Brotherson;Saulo Klahr
研究了正常小鼠和淋巴细胞性脉络丛脑膜炎（LCM）病毒感染肾炎小鼠肾炎系膜内皮系统和网状内皮系统的功能。热聚集的人免疫球蛋白（AlgG）和胶体碳是动物血液和组织中可检测到的溯源物质。LCM病毒感染的蛋白尿（LCM- p）小鼠，与正常小鼠或LCM感染的非蛋白尿（LCM）小鼠相比，在静脉注射AIgG后的所有检查时间，肾小球中AIgG的积累都更多。然而，在正常小鼠和LCM-P小鼠中，肾脏中AIgG的去除率是相同的，表明肾小球系膜清除系统未受损。这表明LCM-P小鼠肾小球中AIgG积累增加可能有其他机制。通过静脉注射AIgG或胶体碳直接检测网状内皮功能。数据表明，在免疫复合物肾小球肾炎模型中，胶体物质从血液中移除的速度比正常小鼠慢。内源性血源性免疫复合物样物质清除不足可能是这些肾病动物肾小球中免疫复合物样物质积累的因素之一。
The function of the mesangial and reticuloendothelial system was evaluated in normal mice and in mice with nephritis induced by lymphocytic choriomeningitis (LCM) virus infection. Heat-aggregated human immunoglobulin (AlgG) and colloidal carbon served as traceable materials which could be detected in animals' blood and tissues. LCM virus-infected proteinuric (LCM-P) mice, as compared to normal mice or LCM-infected nonproteinuric (LCM) mice, had greater accumulation of AIgG in their glomeruli at all times of examination following i.p. injection of AIgG. The removal rate of AIgG from the kidney, however, was the same in normal and LCM-P mice, indicating an unimpaired mesangial clearing system. This suggested that other mechanisms were responsible for the increased glomerular accumulation of AIgG in LCM-P mice. Reticuloendothelial function was examined directly by i.v. injection of AIgG or colloidal carbon. The data demonstrate that in this model of immune complex glomerulonephritis, colloidal material tested was removed from the blood at a slower rate than it was in normal mice. Deficient clearance of endogenous blood-borne immune complex-like material may be one of the factors playing a role in the accumulation of immune complex-like material in the glomeruli of these nephritic animals.