High-intensity interval training can modulate the systemic inflammation and HSP70 in the breast cancer: a randomized control trial
High-intensity interval training can modulate the systemic inflammation and HSP70 in the breast cancer: a randomized control trial
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DOI：
10.1007/s00432-019-02996-y
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发表时间：
2019-10-01
影响因子：
3.6
通讯作者：
Hassan, Zuhair Mohammad
中科院分区：
文献类型：
--
作者：
Alizadeh, Ali Mohammad;Isanejad, Amin;Hassan, Zuhair Mohammad
目的运动训练是近年来癌症患者辅助治疗的一种趋势，但其作用机制尚需进一步研究。本研究的目的是检验在激素治疗期间进行高强度间歇运动训练（HIIT）的患者与接受标准治疗的对照组相比，在低度炎症和HSP 70方面表现出改善的假设。方法将52例非转移性和对乳腺癌有反应的乳腺癌患者随机分为高强度间歇运动训练（HIIT）组（n = 26）和常规治疗组（n = 26）。26）团体。HIIT组在跑步机上进行高强度间歇训练，每周3天，持续12周。根据预测的最大心率确定训练强度。在基线访视时，通过访视者填写的问卷收集人口统计学特征和病史。根据用卡尺测量的参与者非手术侧三头肌髂上嵴处的皮褶厚度估计体脂。VO2max采用1英里Rockport步行试验。在开始运动方案前48小时和最后一次运动后48小时收集血液样品。根据制造商的说明书，使用酶联免疫吸附测定（ELISA）方法测量血清中TNF-α、IL-6、IL-1 β、IL-10和HSP 70水平。通过ELISA测定IL-4和IFN-γ的上清液细胞因子浓度。数据采用协方差分析，在P
Objective Exercise training is recently considered as a trend in adjuvant therapies for cancer patients, but its mechanisms need to be scrutinized further. This study is aimed to test the hypothesis that the patients who perform the high-intensity interval exercise training (HIIT) during hormone therapy would show improvements in low-grade inflammation and HSP70 compared to the controls receiving standard care.Methods Fifty two non-metastatic and hormone-responsive breast cancer patients were randomly assigned to high-intensity interval exercise (HIIT) (n = 26) and usual care (n = 26) groups. The HIIT groups participated in a high-intensity interval training protocol on a treadmill 3 days/week for 12 weeks. The training intensity was determined according to the predicted maximal heart rate. Demographic characteristics and medical history were collected via an interviewer-administered questionnaire at the baseline visit. Body fat was estimated based on skinfold thickness measured with calipers on the participant's nonsurgery side at the triceps, suprailiac crest. VO2max was estimated by 1-Mile Rockport Walk Test. Blood samples were collected 48 h before starting the exercise protocol and 48 h after the last exercise session. TNF-alpha, IL-6, IL-1 beta, IL-10, and HSP70 levels in serum were measured using the enzyme-linked immunosorbent assay (ELISA) method according to the manufacture's instruction. Supernatant cytokine concentrations were determined by ELISA for IL-4 and IFN-gamma. The data were analyzed by ANCOVA test that the pretest values were considered as covariate at P