REPRESSED AND ACTIVE CHROMATIN ISOLATED FROM INTERPHASE LYMPHOCYTES
REPRESSED AND ACTIVE CHROMATIN ISOLATED FROM INTERPHASE LYMPHOCYTES
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DOI：
10.1073/pnas.50.6.1026
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发表时间：
1963-01-01
影响因子：
11.1
通讯作者：
MIRSKY, AE
中科院分区：
文献类型：
--
作者：
FRENSTER, JH;ALLFREY, VG;MIRSKY, AE
可以从间期小牛胸腺淋巴细胞中大量分离出抑制的和活跃的染色质。高达 80% 的间期淋巴细胞 DNA 存在于抑制的染色质部分中。抑制的间期 DNA 表现为浓缩的（异源）染色质，而活跃的间期 DNA 表现为延伸的（真）染色质原纤维。延伸的 (eu-) 染色质部分含有大量快速标记的细胞核 RNA。
Repressed and active chromatin can be isolated in mass from interphase calf thymus lymphocytes. Up to 80% of interphase lymphocyte DNA is found in the repressed chromatin fraction. Repressed interphase DNA appears as condensed (hetero-)chromatin, while active interphase DNA appears as extended (eu-)chromatin fibrils. The extended (eu-) chromatin fraction contains the bulk of the rapidly labeled RNA of the nucleus.