Role of phase angle in the evaluation of effect of an immuno-enhanced formula in post-surgical cancer patients: a randomized clinical trial
Role of phase angle in the evaluation of effect of an immuno-enhanced formula in post-surgical cancer patients: a randomized clinical trial
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DOI：
10.26355/eurrev_201902_17027
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发表时间：
2019-02-01
影响因子：
3.3
通讯作者：
De Lorenzo, A.
中科院分区：
文献类型：
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作者：
Di Renzo, L.;Marchetti, M.;De Lorenzo, A.
目的：肿瘤性疾病通常与营养不良或严重营养不良有关。饮食和营养干预对癌症患者的预后和生活质量越来越重要。用身体成分技术评估营养状况的可解释和可重复的工具似乎是根本。本研究的目的是评估免疫营养素对人体组成参数，炎症反应和营养状况的影响，在第III期的头颈部鳞状细胞癌（HNSCC）。患者和方法：在我们的工作中，50例营养不良的受试者HNSCC分期III招募和治疗口服饮食（OD）或肠内营养（EN）。EN患者在前三天接受肠内标准营养（ESN），然后接受肠内免疫营养（EIN）。结果：EIN治疗后第8天，相位角有明显改善。结论：我们的研究结果表明，免疫营养治疗改善了肿瘤患者的营养状况，支持化疗。相位角不仅是癌症存活率的预测因子。而且还被证明可用于监测营养状况改善以及生化指标。
OBJECTIVE: Neoplastic disease is frequently associated with poor nutritional status or severe malnutrition. Diet and nutritional intervention are becoming increasingly important for prognosis and quality of life in cancer patients. Accessible and repeatable tools for assessing nutritional status with body composition techniques seems to be fundamental. The aim of this study was to evaluate the effects of immunonutrition on body composition parameters, inflammatory response and nutritional status in patients at stage Ill of head and neck squamous carcinoma (HNSCC).PATIENTS AND METHODS: In our work, 50 malnourished subjects with HNSCC staging III were recruited and treated with oral diet (OD) or enteral nutrition (EN). Patient under EN followed, for the first three days, enteral standard nutrition (ESN) and then enteral immunonutrition (EIN). Nutrition state was evaluated on days 0, 3, and 8 through body composition and biochemical analyses.RESULTS: After 8 days, the EIN treatment showed a significant improvement in phase angle. pre-albumin, retinol binding protein and transferrin compared to the OD treatment.CONCLUSIONS: Our results showed that immunonutrition treatment improves the nutritional status of neoplastic patients, supporting chemotherapy. The phase angle is not only a predictor of cancer survival. but has also proved to be useful in the surveillance of nutritional status improvement as well as biochemical indices.