Detection of ERG gene rearrangements and PTEN deletions in unsuspected prostate cancer of the transition zone
Detection of ERG gene rearrangements and PTEN deletions in unsuspected prostate cancer of the transition zone
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DOI：
10.4161/cbt.11.6.14376
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发表时间：
2011-03-15
影响因子：
3.6
通讯作者：
Bismar, Tarek A.
中科院分区：
文献类型：
--
作者：
Liu, Shuhong;Yoshimoto, Maisa;Bismar, Tarek A.
为了评估一组移行区（TZ）的良性PCA肿瘤中ERG重排和PTEN缺失的发生率，我们使用荧光原位杂交技术询问了54例未被怀疑的PCA肿瘤的ERG重排和PTEN缺失。ERG基因重排发生率为12.7%（6/47），66%（4/6）为缺失型。在9/47例（19.1%）病例中检测到PTEN缺失，仅3/47例（6.4%）同时具有PTEN缺失和ERG重排（p = 0.07）。仅ERG重排与> 5%的较高肿瘤体积相关（p = 0.04）; PTEN缺失显示出类似的趋势（p = 0.06）。没有一个标记物显示与Gleason评分相关。总之，尽管TZ和外周区肿瘤具有相似的分子病因学，但它们在ERG和PTEN畸变率方面存在差异。TZ肿瘤中ERG和/或PTEN基因畸变的差异可能指向具有不良行为的肿瘤子集。在TZ肿瘤中实施基于ERG和PTEN组织的FISH检测的其他研究是必要的，以证实这些生物标志物在偶发PCA男性管理中的潜在临床价值。
To assess the incidence of ERG rearrangements and PTEN deletions in a group of prognostically favorable PCA tumors of the transition zone (TZ).We interrogated 54 unsuspected PCA tumors using fluorescence in-situ hybridization for ERG rearrangements and PTEN deletions. ERG rearrangements were detected in 6/47 (12.7%) cases with 4/6 (66%) occurring by deletion. PTEN deletions were detected in 9/47 (19.1%) cases with only 3/47 (6.4%) having both PTEN losses and ERG rearrangements (p = 0.07). Only ERG rearrangements were associated with higher tumor volume > 5% (p = 0.04); PTEN deletions showed similar trends (p = 0.06). None of the markers showed association with Gleason score. In conclusion, although TZ and peripheral zone tumors share similar molecular etiologies, they exhibit differences in the rates of ERG and PTEN aberrations. The differences of ERG and/or PTEN genetic aberrations in TZ tumors may point toward a subset of tumors with adverse behavior. Additional studies implementing ERG and PTEN tissue-based FISH assays in tumors of the TZ are warranted to substantiate the potential clinical value of these biomarkers in the management of men with incidental PCA.