Chemical strategies for the covalent modification of filamentous phage.
Chemical strategies for the covalent modification of filamentous phage.
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DOI：
10.3389/fmicb.2014.00734
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发表时间：
2014
影响因子：
5.2
通讯作者：
Francis MB
中科院分区：
文献类型：
--
作者：
Bernard JM;Francis MB
历史上，丝状噬菌体由于其将基因型与表型联系起来的能力而被认为是噬菌体展示的主力。最近，丝状噬菌体支架已被证明是强大的领域以外的噬菌体展示技术，如分子成像，癌症研究和材料，疫苗开发。病毒体作为各种应用平台的能力严重依赖于具有多种功能的噬菌体外壳蛋白的功能化。外壳蛋白的遗传修饰是使病毒粒子功能化的最广泛使用的策略;然而，补充的化学修饰策略可以有助于使可以开发的材料范围多样化。这篇综述强调了丝状噬菌体的化学修饰的最新进展，以及在功能化的病毒粒子所涉及的一些挑战。
Historically filamentous bacteriophage have been known to be the workhorse of phage display due to their ability to link genotype to phenotype. More recently, the filamentous phage scaffold has proven to be powerful outside the realm of phage display technology in fields such as molecular imaging, cancer research and materials, and vaccine development. The ability of the virion to serve as a platform for a variety of applications heavily relies on the functionalization of the phage coat proteins with a wide variety of functionalities. Genetic modification of the coat proteins has been the most widely used strategy for functionalizing the virion; however, complementary chemical modification strategies can help to diversify the range of materials that can be developed. This review emphasizes the recent advances that have been made in the chemical modification of filamentous phage as well as some of the challenges that are involved in functionalizing the virion.
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