Selective modulation of cortical population dynamics during neuroprosthetic skill learning.
Selective modulation of cortical population dynamics during neuroprosthetic skill learning.
复制标题
神经假体技能学习过程中皮质种群动态的选择性调节。
DOI：
10.1038/s41598-022-20218-3
复制
发表时间：
2022-09-24
影响因子：
4.6
通讯作者：
Carmena, Jose M
中科院分区：
文献类型：
--
作者：
Zippi, Ellen L;You, Albert K;Ganguly, Karunesh;Carmena, Jose M
脑机接口（BMI）提供了一个框架，用于研究皮层群体动态如何在任务中的学习过程中演变，其中神经活动和行为之间的映射是精确定义的。学习控制 BMI 与神经元群体中协调神经动力学的出现有关，神经元群体的活动作为 BMI 解码器的直接输入（直接子群体）。虽然之前的研究表明，相对于活动未直接输入 BMI 解码器的群体（间接亚群），该群体的放电率调节存在差异性改变，但对于这些群体中皮质群体动态的学习相关变化如何进行比较，我们知之甚少。为了研究这一点，我们在两只猕猴学会控制 BMI 时监测了直接和间接亚群。我们发现，虽然合并群体增加了协调的神经动力学，但这种协调的增加主要是由直接亚群体的变化驱动的。这些发现表明，运动皮层通过在学习过程中增加整个群体的神经方差来完善皮质动力学，并且与行为因果相关的亚群体中的放电活动具有更明显的协调性。
Brain-machine interfaces (BMIs) provide a framework for studying how cortical population dynamics evolve over learning in a task in which the mapping between neural activity and behavior is precisely defined. Learning to control a BMI is associated with the emergence of coordinated neural dynamics in populations of neurons whose activity serves as direct input to the BMI decoder (direct subpopulation). While previous work shows differential modification of firing rate modulation in this population relative to a population whose activity was not directly input to the BMI decoder (indirect subpopulation), little is known about how learning-related changes in cortical population dynamics within these groups compare.To investigate this, we monitored both direct and indirect subpopulations as two macaque monkeys learned to control a BMI. We found that while the combined population increased coordinated neural dynamics, this increase in coordination was primarily driven by changes in the direct subpopulation. These findings suggest that motor cortex refines cortical dynamics by increasing neural variance throughout the entire population during learning, with a more pronounced coordination of firing activity in subpopulations that are causally linked to behavior.