Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
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DOI：
10.2807/1560-7917.es.2020.25.32.2001483
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发表时间：
2020-08-13
期刊：
影响因子：
19
通讯作者：
Gopal, Robin
中科院分区：
文献类型：
--
作者：
Singanayagam, Anika;Patel, Monika;Gopal, Robin
在轻度至中度冠状病毒病患者中，上呼吸道病毒载量在症状出现前后达到峰值，传染性病毒持续10天（n = 324个样本分析）。RT-PCR周期阈值（Ct）值与可培养病毒密切相关。在Ct值为35的样本中，培养病毒的概率降至8%，在发病10天后降至6%；无症状者与有症状者相似。无症状者是可传播病毒的来源。
Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.