MOLECULAR-STRUCTURE OF FIBRINOGEN
MOLECULAR-STRUCTURE OF FIBRINOGEN
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DOI：
10.1111/j.1749-6632.1972.tb16323.x
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发表时间：
1972-01-01
影响因子：
5.2
通讯作者：
BLOMBACK, M
中科院分区：
文献类型：
--
作者：
BLOMBACK, B;BLOMBACK, M
The role of fibrinogen in the living organism is not easily narrowed down to the area of hemostasis, when we consider that low levels of fibrinogen can be tolerated without excessive bleeding ie, in afibrinogenemia and defibrinated states. Fibrinogen may play a role not only in hemostasis, but also in fibroblast proliferation and defense mechanisms against infection. Comparative studies of different animal phyla have shown that aggregating proteins are also common in invertebrates in which cellular mechanisms primarily are responsible for hemostasis.A century has passed since Olof Hammarsten and Denis de Commercy performed their pioneering studies on thL isolation of fibrinogen and its transformation into fibrin. Since the turn of the century, we have gained considerable information regarding the physical and molecular properties of this protein. Several reviews have been written on the topic, and the reader is referred to these for further Despite all available information, today we can only speculate on how the fibrinogen units are arranged in the fibrin fiber, and which forces or bonds keep them together during the different phases of aggregation. This problem is of prime importance for us present here today, since the alignment of the fibrinogen units seems to determine the substrate specificity of factor XI11 in the cross-linking reaction.
