Effect of Litchi chinensis on adipose and hepatic tissues in rats with obesity and non-alcoholic fatty liver disease (NAFLD)
Effect of Litchi chinensis on adipose and hepatic tissues in rats with obesity and non-alcoholic fatty liver disease (NAFLD)
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DOI：
10.1016/j.jssas.2017.06.002
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发表时间：
2017-06
影响因子：
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通讯作者：
A. Alexander-Aguilera;Isaac Aguirre-Maldonado;Jorge Rodríguez Antolín;Leticia Nicolás Toledo;Ida Soto Rodríguez-Ida-Soto
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文献类型：
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作者：
A. Alexander-Aguilera;Isaac Aguirre-Maldonado;Jorge Rodríguez Antolín;Leticia Nicolás Toledo;Ida Soto Rodríguez-Ida-Soto
荔枝提取物作为改善糖尿病、肥胖症及其并发症（如非酒精性脂肪肝）的补充治疗剂的用途已被研究，以确定荔枝是否可以在肥胖症的发展过程中充当功能性食物。目的：研究荔枝果肉对Wistar大鼠脂肪和肝脏组织的影响，探讨荔枝果肉对肥胖和脂肪肝形成的影响。方法：采用代谢综合征大鼠模型，分为对照组（C组）、荔枝-蔗糖组（Lch-Suc组）和荔枝无蔗糖组（Lch组）。荔枝果肉的剂量为40%p/v，持续5周。然而，对Wistar大鼠肥胖和脂肪肝发生过程中肝组织的肥大知之甚少。方法学：使用以下四组大鼠：对照（C）、代谢综合征（MS）、荔枝-蔗糖（Lch-Suc）和不含蔗糖的荔枝（Lch）。荔枝果肉的剂量为40%p/v，持续5周。结果：我们观察到C组和MS组之间腹部脂肪重量的差异。Lch组的脂肪组织重量、甘油三酯（36%）和胆固醇（11%）显著低于MS组。MS、Lch-Suc和Lch组显示大泡性脂肪变性，而C组未发现。最后，Lch组中小脂肪细胞（面积< 2000 µm2）的数量高于MS组和Lch-Suc组。结论：饮用水中的荔枝果肉影响脂肪组织的细胞动力学，减少脂肪细胞的肥大，并产生对抗Wistar大鼠肝组织中脂肪积累的效果。
The use of lychee extract as a supplemental therapeutic to ameliorate diabetes, obesity and its complications, such as non-alcoholic fatty liver disease, has been investigated to determine whether lychee can act as a functional food during the development of obesity. Objective: to evaluate the effect of the pulp ofLitchi chinensisdietary on adipose and hepatic tissues associated with the development of obesity and fatty liver in Wistar rats. Methodology: four groups of rats were used control group (C), Metabolic syndrome (MS) Lychee-Sucrose (Lch-Suc) and Lychee without sucrose (Lch). The dose of pulp of lychee was 40% p/v for 5 weeks. However, very little is known about the hypertrophy of hepatic tissues during the development of obesity and fatty liver in Wistar rats. Methodology: The following four groups of rats were used: control (C), metabolic syndrome (MS), Lychee-Sucrose (Lch-Suc) and Lychee without sucrose (Lch). The dosage of lychee pulp was 40% p/v for 5 weeks. Results: We observed differences in the abdominal fat weights between the C and MS groups. In the Lch group, the adipose tissue weight, triglycerides (36%) and cholesterol (11%) were significantly lower than those in the MS group. The MS, Lch-Suc and Lch groups showed macrovesicular steatosis, which was not found in the C group. Finally, the number of small adipocytes (areas < 2000 µm2) was higher in the Lch group than in the MS group and the Lch-Suc group. Conclusion: Lychee pulp in drinking water affected the cellular dynamics of adipose tissue, reducing the hypertrophy of adipocytes and exerting an effect that countered the accumulation of fat in the liver tissue of Wistar rats.