HEPARIN INTERACTS WITH A SELENOPROTEIN IN HUMAN-PLASMA
HEPARIN INTERACTS WITH A SELENOPROTEIN IN HUMAN-PLASMA
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DOI：
10.1016/0162-0134(88)80004-7
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发表时间：
1988-08-01
影响因子：
3.9
通讯作者：
MARTENSSON, B
中科院分区：
文献类型：
--
作者：
AKESSON, B;MARTENSSON, B
在Sephadex G-150凝胶层析中，人血清含硒峰的Kav为0.19，而在肝素化血浆层析中，该峰的Kav为0.01，表明肝素与主要含硒蛋白之间存在相互作用。鱼精蛋白的加入消除了肝素的作用。肝素相互作用蛋白与谷胱甘肽过氧化物酶不相同。这些数据解释了由于使用不同抗凝剂而导致血浆中硒分布的一些差异。
The major selenium-containing peak at gel filtration of human serum on Sephadex G-150 had a Kav of 0.19, but at chromatography of heparinized plasma this peak had a Kav of 0.01, indicating an interaction between heparin and a major selenium-containing protein. The addition of protamine abolished the effect of heparin. The heparin-interacting protein was not identical to glutathione peroxidase. The data explain some previous discrepancies on selenium distribution in plasma due to the use of different anticoagulants.