Enhanced fixation of implants by bone ingrowth to titanium fiber mesh: Effect of incorporation of hydroxyapatite powder
Enhanced fixation of implants by bone ingrowth to titanium fiber mesh: Effect of incorporation of hydroxyapatite powder
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DOI：
10.1002/jbm.b.30282
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发表时间：
2005-10-01
影响因子：
3.4
通讯作者：
Moriya, H
中科院分区：
文献类型：
--
作者：
Tsukeoka, T;Suzuki, M;Moriya, H
骨和植入物材料之间的紧密固定对于全膝关节置换术（TKA）和全髋关节置换术（THA）等手术的成功结局非常重要。钛纤维网是一种有吸引力的结构，用于通过骨长入纤维之间的间隙在骨和植入物之间建立紧密固定。增强骨长入不仅是为了紧密固定，也是为了快速恢复。我们的假设是，羟基磷灰石（HA）颗粒的存在确保了骨长入的改善，并且可以通过在钛纤维之间的空间中机械锚定骨来获得长期稳定性。在这项研究中，我们验证了我们的假设，在体内实验，狗股骨。通过将HA颗粒浸入HA与羟丙基纤维素在乙醇溶液中的浆料中，将HA颗粒掺入涂覆在钛合金棒上的钛纤维网中。将标本植入3周、5周和8周，然后与未使用HA的标本的结果进行比较。通过推出试验评价结合强度，并通过分析软件进行组织形态计量学测量，计算骨长入的平均值。在3周和5周时，观察到HA结合种植体的样本具有显著更高的结合强度，并且在3周时测量到钛纤维网内部深处有更大的骨长入。我们提出的方法具有不需要高温的额外优点，高温可能会导致HA粉末的特性发生变化，如相变，晶粒生长和分解。此外，这种不经高温处理的HA粉末掺入技术允许使用几种类型的金属纤维网，以及应用于由有机聚合物制成的纤维网。我们的结论是，这种简单的钛纤维网与HA粉末的修改，可以提高种植体在术后初期的骨固定。(c)2005 Wiley Periodicals，Inc.
Tight fixation between bone and implant materials is of great importance for a successful outcome of procedures such as total knee arthroplasty (TKA) and total hip arthroplasty (THA). Titanium fiber mesh is an attractive structure for the establishment of tight fixation between bone and implant by bone ingrowth into the spaces among the fibers. Enhancement of bone ingrowth is desired not only for tight fixation but also for a fast recovery. Our hypothesis is that just the presence of hydroxyapatite (HA) particles ensures improved bone ingrowth, and that long-term stability can be obtained by mechanical anchoring of bone in the spaces among titanium fibers. In this study, we examine our hypothesis by in vivo experiment using dog femur. HA particles were incorporated in titanium fiber mesh coated on titanium alloy rod by dipping in a slurry of HA with hydroxy-propyl-cellulose in an ethanol solution. Specimens were implanted for 3, 5, and 8 weeks, and were then compared with the results from specimens without the use of HA. Bonding strength was evaluated by push-out test, and histomorphometric measurements were made with analysis software to calculate the average value of bone ingrowth. A significantly higher bonding strength was observed for the specimens with HA-incorporated implant at 3 and 5 weeks, and larger bone ingrowth deep inside the titanium fiber mesh was measured at 3 weeks. Our proposed method has the additional advantage of not requiring a high temperature that may result in changes in characters of HA powder such as phase transition, grain growth, and decomposition. Moreover, this technique of HA powder incorporation without high-temperature treatment allows the use of several types of metallic fiber mesh, as well as the application to fiber mesh made of organic polymers. We conclude that this simple modification of titanium fiber mesh with HA powder can improve the fixation of implant to bone in the initial stage after operation. (c) 2005 Wiley Periodicals, Inc.