High waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women
High waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women
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DOI：
10.1016/j.dsx.2018.11.043
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发表时间：
2019-01-01
影响因子：
10
通讯作者：
del Carmen Ranilla-Seguin, Vitalia
中科院分区：
文献类型：
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作者：
Benites-Zapata, Vicente A.;Toro-Huamanchumo, Carlos J.;del Carmen Ranilla-Seguin, Vitalia
目的：评估正常体重女性样本中高腰臀比 (WHR) 水平与口服葡萄糖耐量试验 (OGTT) 后高胰岛素抵抗 (IR) 或高胰岛素血症之间的关系。方法：我们对 2012 年至 2016 年在秘鲁利马一家私人诊所门诊就诊的甲状腺功能正常的非糖尿病女性进行了一项横断面分析研究。根据是否存在高腰臀比将参与者分为两组OGTT 后胰岛素水平、IR 或高胰岛素血症。我们认为腰臀比值 > 0.85 为高水平。 IR被定义为稳态模型评估（HOMA-IR）值> 2.39，OGTT后高胰岛素血症定义为摄入75克葡萄糖120分钟后血清胰岛素值> 80 U/mL。我们精心设计了粗略和调整后的泊松广义线性模型，以评估高腰臀比水平与 OGTT 后 IR 或高胰岛素血症之间的关联，并报告患病率 (PR) 及其各自的 95% 置信区间 (95%CI)。 结果：我们分析了 248 名甲状腺功能正常、非糖尿病和正常体重女性的数据。高腰臀比水平的患病率为 68.9% (n = 171)，而 OGTT 后 IR 和高胰岛素血症的患病率分别为 25% (n = 62) 和 15.3% (n = 38)。 WHR 值与 HOMA-IR（r = 0.307；p < 0.001）和 OGTT 后血清胰岛素（r = 0.260；p < 0.001）呈正相关。在调整后的模型中，高腰臀比水平与 IR（aPR = 2.63；95%CI：1.39-5.01）和 OGTT 后高胰岛素血症（aPR = 2.35；95%CI：1.03-5.38）相关。结论：高腰臀比水平与我们研究中使用的两种 IR 标志物相关，似乎是评估甲状腺功能正常的 IR 的有用人体测量指标没有 2 型糖尿病的正常体重女性。 (C) 2018 年印度糖尿病。由爱思唯尔有限公司出版。保留所有权利。
Aim: To assess the association between high waist-to-hip ratio (WHR) levels and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of normal-weight women.Methods: We conducted an analytical cross-sectional study in euthyroid non-diabetic women, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high WHR levels, IR or hyperinsulinemia after OGTT. We considered WHR values > 0.85 as high levels. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value > 2.39 and hyperinsulinemia after OGTT as a serum insulin value > 80 U/ mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high WHR levels and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI).Results: We analyzed the data of 248 euthyroid, non-diabetic and normal-weight women. The prevalence of high WHR levels was 68.9% (n = 171) while the prevalence of IR and hyperinsulinemia after OGTT was 25% (n = 62) and 15.3% (n = 38), respectively. WHR values were positively correlated with HOMA-IR (r = 0.307; p < 0.001) and serum insulin after OGTT (r = 0.260; p < 0.001). In the adjusted model, high WHR levels were associated with both IR (aPR = 2.63; 95%CI: 1.39-5.01) and hyperinsulinemia after OGTT (aPR = 2.35; 95%CI: 1.03-5.38).Conclusion: High WHR levels were associated with both IR markers used in our study, appearing to be a useful anthropometric indicator to assess IR in euthyroid normal-weight women without type 2 diabetes mellitus. (C) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.