Developmental toxicity of organotin compounds in animals
Developmental toxicity of organotin compounds in animals
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DOI：
10.3389/fmars.2014.00039
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发表时间：
2014-09
影响因子：
3.7
通讯作者：
Lijiao Wu;Zhenhuang Chen;Jingmin Zhu;Lingling Hu;Xiao Huang;Huahong Shi
中科院分区：
文献类型：
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作者：
Lijiao Wu;Zhenhuang Chen;Jingmin Zhu;Lingling Hu;Xiao Huang;Huahong Shi
有机锡化合物（OTs）已被用作杀虫剂和农业中的杀生物剂。国际海事组织于2001年在全球范围内禁止在水处理系统中使用OTs，因为它们具有高毒性。然而，OTs仍然在环境中被检测到，并对生态系统构成威胁。几个研究小组总结了分析方法，环境归宿，生物化学，生殖毒性和作用机制的OTs。本文综述了OTs对海胆、海鞘、贻贝和鱼类等多种生物的发育毒性。不仅不同物种对OT暴露的敏感性存在差异，而且同一物种在不同发育阶段对OT暴露的敏感性也存在差异。虽然已经提出了一些假说来解释OTs的发育毒性，但仍然需要确凿的证据。
Organotin compounds (OTs) have been used as biocides in antifouling paints and agriculture. The IMO introduced a global ban on the use of OTs in antifouling systems in 2001 due to their high toxicity. However, OTs have still been detected in the environment and pose a threat to the ecosystem. Several research groups have summarized the analytical methods, environmental fate, biochemistry, reproductive toxicity and mechanisms of actions of OTs. Here, we reviewed the developmental toxicity of OTs in various organisms such as sea urchin, ascidian, mussel and fish. The differences in sensitivity to OT exposure exist not only in different species but also at different stages in the same species. Though some hypotheses have been proposed to explain the developmental toxicity of OTs, the solid evidences are greatly in need.