Estimation of serum zinc and copper in children with acute diarrhea
Estimation of serum zinc and copper in children with acute diarrhea
复制标题
急性腹泻患儿血清锌和铜的测定
DOI：
10.1385/bter:114:1:121
复制
发表时间：
2007
影响因子：
3.9
通讯作者：
P. Sharma
中科院分区：
文献类型：
--
作者：
R. Arora;S. Kulshreshtha;G. Mohan;M. Singh;P. Sharma
事实上，腹泻是一种营养性疾病，也是一种液体和电解质流失的疾病。死于腹泻的儿童，尽管脱水得到了很好的控制，但通常营养不良，而且往往严重营养不良。在这项研究中，我们测定了急性腹泻儿童标准口服补液溶液（ORS）治疗前后血清锌和铜的水平，并将其与腹泻的持续时间和严重程度相关联。110名儿童患有急性腹泻。在入选时和标准ORS治疗后，对这些儿童的血清锌和铜水平进行评估。这项研究表明，患有急性腹泻的儿童与正常儿童相比，血清锌和铜浓度分别下降了13.1%和12.8%，具有统计学意义。在标准ORS治疗后，这些水平分别进一步降低22.6%和22.4%。我们的研究表明，血浆锌和铜水平较低的儿童遭受更严重和更长时间的腹泻。补充锌和铜可以添加到标准的口服补液盐治疗中，以减少儿童急性腹泻相关的发病率和死亡率。
Diarrhea is, in reality, as much a nutritional disease as one of fluid and electrolyte loss. Children who die from diarrhea, despite good management of dehydration, are usually malnourished and often severely so. In this study, we determined the serum levels of zinc and copper before and after standard oral rehydration solution (ORS) therapy in children with acute diarrhea and correlated it with diarrheal duration and severity. One hundred ten children suffering from acute diarrhea were included. Serum zinc and copper levels of these children were estimated at the time of enrollment and after treatment with standard ORS therapy. This study shows that children suffering from acute diarrhea show a statistically significant decrease of 13.1% and 12.8% in serum zinc and copper concentrations, respectively, compared to normal. These levels further decrease by 22.6% and 22.4%, respectively, after treatment with standard ORS therapy. Our study shows that children with the lower plasma zinc and copper levels suffered with more severe and longer duration of diarrhea. Zinc and copper supplementation could be added to standard ORS therapy for the reduction in morbidity and mortality associated with acute diarrhea in children.