Palladium/L-Proline-Catalyzed Enantioselective α-Arylative Desymmetrization of Cyclohexanones
Palladium/L-Proline-Catalyzed Enantioselective α-Arylative Desymmetrization of Cyclohexanones
复制标题
钯/L-脯氨酸催化环己酮的对映选择性 α-芳基去对称化
DOI：
10.1021/jacs.6b01214
复制
发表时间：
2016-04-27
影响因子：
15
通讯作者：
Jia, Yi-Xia
中科院分区：
文献类型：
--
作者：
Liu, Ren-Rong;Li, Bao-Le;Jia, Yi-Xia
研究了钯/L-脯氨酸催化环己酮的α-芳基化去对称化反应。这种新的α-芳基化反应策略以良好的产率和良好的对映选择性（高达99%ee）得到了一系列具有α-羰基叔立体中心的光学活性吗啉衍生物。
A highly enantioselective palladium/L-proline-catalyzed alpha-arylative desymmetrization of cyclohexanones was developed. The new strategy for alpha-arylation reaction led to a series of optically active morphan derivatives bearing a-carbonyl tertiary stereo centers in good yields with excellent enantioselectivities (up to 99% ee).