Increased body weight in mice lacking mu-opioid receptors
Increased body weight in mice lacking mu-opioid receptors
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DOI：
10.1097/01.wnr.0000221829.87974.ad
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发表时间：
2006-06-26
期刊：
影响因子：
1.7
通讯作者：
Ikeda, Kazutaka
中科院分区：
文献类型：
--
作者：
Han, Wenhua;Hata, Harumi;Ikeda, Kazutaka
Opioids have been suggested to affect feeding behaviour. To clarify the role of p-opioid receptors in feeding, we measured several parameters relating to food intake in p-opioid receptor knockout mice. Here, we show that the knockout mice had increased body weight in adulthood, although the intake amount of standard food was similar between the wild-type and knockout littermates. Serum markers for energy homeostasis were not significantly altered in the knockout mice. Hypothalamic neuropeptide YmRNA, however, was higher in knockouts than in wild-type mice. Our results suggest that the up-regulated expression of neuropeptide YmRNA might contribute to the increased weights of adult mu-opioid receptor knockout mice.
